New Models to Predict the Acute and Chronic Toxicities of Representative Species of the Main Trophic Levels of Aquatic Environments

To assess the impact of chemicals on an aquatic environment, toxicological data for three trophic levels are needed to address the chronic and acute toxicities. The use of non-testing methods, such as predictive computational models, was proposed to avoid or reduce the need for animal models and speed up the process when there are many substances to be tested. We developed predictive models for Raphidocelis subcapitata, Daphnia magna, and fish for acute and chronic toxicities. The random forest machine learning approach gave the best results. The models gave good statistical quality for all endpoints. These models are freely available for use as individual models in the VEGA platform and for prioritization in JANUS software.

Automated summary

This study developed predictive models for acute and chronic toxicities in Raphidocelis subcapitata, Daphnia magna, and fish, with the random forest machine learning approach yielding the best results. The models showed good statistical quality for all endpoints, and are freely available for use as individual models in the VEGA platform and for prioritization in JANUS software.