期刊
INFECTION
卷 45, 期 3, 页码 309-321出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s15010-016-0975-y
关键词
Hepatitis C; HIV; Men having sex with men; Meta-analysis; Prospective study; Retrospective study
资金
- AbbVie
- Boehringer Ingelheim
- Bristol Myers Squibb
- Gilead Sciences
- Janssen
- Merck Sharp Dome
- Pfizer
- Roche
- ViiV Healthcare
- University of Zurich's Clinical research Priority Program (CRPP)
There is a need for systematic reviews and meta-analyses to synthesize the epidemiology, and the riskfactors for hepatitis C virus (HCV) among HIV-coinfected and HIV negative men who have sex with men (MSM). A meta-analysis of 28 studies was carried out by pooling HCV incidence data of HIV-coinfected and HIV negative MSM. Differences in incidence outcome depending on the prospective or retrospective nature of the individual studies were investigated. The pooled incidence of HCV in MSM was 6.3 per 1000 person-years (95% CI 5.0-7.5). The overall estimated incidence was 19-fold higher in HIV positive compared to HIV negative MSM living in resource-rich countries. This result was confirmed when the analysis was restricted to high-quality studies. Factors associated with an increased risk for incident HCV included behavioural factors (sexual risk behaviour and recreational drug use) as well as biological characteristics (HIV coinfection and a recent history of syphilis). In conclusion, incident HCV predominantly affects HIV positive MSM. The incidence rate varied largely between studies, factors such as study design might play an important role.
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