New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27

In the course of screening new streptomycete strains, the strain Streptomyces sp. Cl 58-27 caught our attention due to its interesting secondary metabolite production profile. Here, we report the isolation and characterization of an ansamycin natural product that belongs structurally to the already known kendomycins. The structure of the new kendomycin E was elucidated using NMR spectroscopy, and the corresponding biosynthetic gene cluster was identified by sequencing the genome of Streptomyces sp. Cl 58-27 and conducting a detailed analysis of secondary metabolism gene clusters using bioinformatic tools.

Automated summary

During the screening of new streptomycete strains, the strain Streptomyces sp. Cl 58-27 was found to produce a novel ansamycin natural product, kendomycin E, structurally similar to kendomycins. The structure of kendomycin E was elucidated using NMR spectroscopy, and its biosynthetic gene cluster was identified through genome sequencing and bioinformatic analysis of Streptomyces sp. Cl 58-27.