相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Optimization of a transient antibody expression platform towards high titer and efficiency
Elizabeth Greene et al.
BIOTECHNOLOGY JOURNAL (2021)
A review of formulations of commercially available antibodies
Robert G. Strickley et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2021)
Ultradilute Measurements of Self-Association for the Identification of Antibodies with Favorable High-Concentration Solution Properties
Charles G. Starr et al.
MOLECULAR PHARMACEUTICS (2021)
Highly sensitive detection of antibody nonspecific interactions using flow cytometry
Emily K. Makowski et al.
MABS (2021)
Antibodies to watch in 2020
Helene Kaplon et al.
MABS (2020)
Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design
James R. Apgar et al.
PLOS ONE (2020)
Physicochemical Rules for Identifying Monoclonal Antibodies with Drug-like Specificity
Yulei Zhang et al.
MOLECULAR PHARMACEUTICS (2020)
A single molecular descriptor to predict solution behavior of therapeutic antibodies
Jonathan S. Kingsbury et al.
SCIENCE ADVANCES (2020)
Mitigation of liquid-liquid phase separation of a monoclonal antibody by mutations of negative charges on the Fab surface
Tatsuji Matsuoka et al.
PLOS ONE (2020)
Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies
Amita Datta-Mannan et al.
MABS (2020)
Five computational developability guidelines for therapeutic antibody profiling
Matthew I. J. Raybould et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Improving the Developability of an Antigen Binding Fragment by Aspartate Substitutions
Laila I. Salchnini et al.
BIOCHEMISTRY (2019)
Looking for therapeutic antibodies in next-generation sequencing repositories
Konrad Krawczyk et al.
MABS (2019)
Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules
Susan R. Crowell et al.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY (2019)
Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics
Nicole M. Piche-Nicholas et al.
MABS (2018)
Biophysical and Sequence-Based Methods for Identifying Monovalent and Bivalent Antibodies with High Colloidal Stability
Magfur E. Alam et al.
MOLECULAR PHARMACEUTICS (2018)
Monoclonal antibodies as immunomodulatory therapy against cancer and autoimmune diseases
Umbreen Hafeez et al.
CURRENT OPINION IN PHARMACOLOGY (2018)
Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics
Lindsay B. Avery et al.
MABS (2018)
Rational optimization of a monoclonal antibody for simultaneous improvements in its solution properties and biological activity
Sandeep Kumar et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2018)
Net charge of antibody complementarity-determining regions is a key predictor of specificity
Lilia A. Rabia et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2018)
Monoclonal Antibodies: A Review
Surjit Singh et al.
CURRENT CLINICAL PHARMACOLOGY (2018)
Biophysical properties of the clinical-stage antibody landscape
Tushar Jain et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Facile Preparation of Stable Antibody-Gold Conjugates and Application to Affinity-Capture Self-Interaction Nanoparticle Spectroscopy
Steven B. Geng et al.
BIOCONJUGATE CHEMISTRY (2016)
Therapeutic Monoclonal Antibodies for the Treatment of Chronic Obstructive Pulmonary Disease
Maria Gabriella Matera et al.
DRUGS (2016)
Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity
Jayant Arora et al.
MABS (2016)
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo
Claire L. Dobson et al.
SCIENTIFIC REPORTS (2016)
The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies
Amita Datta-Mannan et al.
MABS (2015)
Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics
Amita Datta-Mannan et al.
MABS (2015)
Rational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobic versus electrostatic inter-molecular interactions
Pilarin Nichols et al.
MABS (2015)
Solubility Challenges in High Concentration Monoclonal Antibody Formulations: Relationship with Amino Acid Sequence and Intermolecular Interactions
Mariya Pindrus et al.
MOLECULAR PHARMACEUTICS (2015)
Discovery of highly soluble antibodies prior to purification using affinity-capture self-interaction nanoparticle spectroscopy
Jiemin Wu et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2015)
Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge
Bing Li et al.
MABS (2014)
Dipole-Dipole Interaction in Antibody Solutions: Correlation with Viscosity Behavior at High Concentration
Shubhadra N. Singh et al.
PHARMACEUTICAL RESEARCH (2014)
Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties
Li Li et al.
PHARMACEUTICAL RESEARCH (2014)
In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability
Vikas K. Sharma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass - Prediction of viscosity through protein-protein interaction measurements
Martin S. Neergaard et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)
The Role of Amino Acid Sequence in the Self-Association of Therapeutic Monoclonal Antibodies: Insights from Coarse-Grained Modeling
Anuj Chaudhri et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2013)
Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics
Daniela Bumbaca et al.
AAPS JOURNAL (2012)
Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter
Brian D. Connolly et al.
BIOPHYSICAL JOURNAL (2012)
Monoclonal antibody therapeutics: history and future
Nicholas A. P. S. Buss et al.
CURRENT OPINION IN PHARMACOLOGY (2012)
Viscosity behavior of high-concentration monoclonal antibody solutions: Correlation with interaction parameter and electroviscous effects
Sandeep Yadav et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2012)
The Influence of Charge Distribution on Self-Association and Viscosity Behavior of Monoclonal Antibody Solutions
Sandeep Yadav et al.
MOLECULAR PHARMACEUTICS (2012)
A strategy for risk mitigation of antibodies with fast clearance
Isidro Hoetzel et al.
MABS (2012)
Assessment of Net Charge and Protein-Protein Interactions of Different Monoclonal Antibodies
Christian Lehermayr et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4
Daniela Bumbaca et al.
MABS (2011)
Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies
Sandeep Yadav et al.
PHARMACEUTICAL RESEARCH (2011)
Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics
C. Andrew Boswell et al.
BIOCONJUGATE CHEMISTRY (2010)
Factors Affecting the Viscosity in High Concentration Solutions of Different Monoclonal Antibodies
Sandeep Yadav et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2010)
Specific Interactions in High Concentration Antibody Solutions Resulting in High Viscosity
Sandeep Yadav et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2010)
The functional capacity of the natural amino acids for molecular recognition
Sara Birtalan et al.
MOLECULAR BIOSYSTEMS (2010)
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation
Hugo Mouquet et al.
NATURE (2010)
Reduced elimination of IgG antibodies by engineering the variable region
T. Igawa et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2010)
The intrinsic contributions of tyrosine, serine, glycine and arginine to the affinity and specificity of antibodies
Sara Birtalan et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosity
Sonoko Kanai et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2008)
Elimination mechanisms of therapeutic monoclonal antibodies
MA Tabrizi et al.
DRUG DISCOVERY TODAY (2006)
Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution
J Liu et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2005)
Predominant autoantibody production by early human B cell precursors
H Wardemann et al.
SCIENCE (2003)
Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans
ES Ward et al.
INTERNATIONAL IMMUNOLOGY (2003)
Enhanced cellular uptake and transport of polyclonal immunoglobulin G and Fab after their cationization
GY Hong et al.
JOURNAL OF DRUG TARGETING (2000)