期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 66, 期 10, 页码 -出版社
WILEY
DOI: 10.1002/mnfr.202101064
关键词
fructo-oligosaccharide; galacto-oligosaccharide; gut microbiota; iron absorption; iron deficiency anemia
资金
- National Natural Science Foundation of China [31601472]
- Guangdong Province Zhujiang Talent Program [2019ZT08H476]
- Shenzhen Science and Technology Program [KQTD20180412181334790]
- New Zealand National Science Challenge High-Value-Nutrition (HVN) program, via the Ministry for Business, Innovation and Employment (MBIE) [3719728]
This study investigates the mechanism of how GOS/FOS affect iron absorption in an iron-deficient rat model and determines the optimum dose of GOS.
Scope Iron deficiency anemia (IDA) in children is one of the most common nutrition-related health conditions worldwide. Prebiotic oligosaccharides, fructo-oligosaccharide (FOS) and galacto-oligosaccharides (GOS), have shown to affect iron absorption in anemic subjects, but the results in previous studies are inconsistent, thus the underlying mechanism and the effective dose of GOS in mitigating anemia remain unclear. Methods and Results The present study aims to investigate the mechanism of how GOS/FOS affect iron absorption in an iron-deficient growing rat model from the perspectives of protein expression and gut microbiota, and determine the optimum dose of GOS. Iron-deficient models are established by providing young rats diet without iron addition for 14 days. Later, iron-deficient rats are provided with standard rat chows supplemented with 0%, 3%, 5%, 10% GOS, and 10% FOS for 21 days. The results show that >= 5% GOS supplementation in diet improves iron status and significantly impacts iron-binding/transport protein expression. Furthermore, a dose-dependent modulating effect of GOS on gut microbiota is determined. Conclusion For the first time, the present study provides evidence that GOS supplementation induces a dose-response effect on iron absorption and gut microbiota in the established model, suggesting a positive role of GOS in ameliorating IDA in children.
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