期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 65, 期 23, 页码 -出版社
WILEY
DOI: 10.1002/mnfr.202100381
关键词
dietary restriction; fatty acid oxidation; fatty liver disease; lipolysis; obesity
资金
- National Natural Science Foundation of China [31630036]
- Ministry of Science and Technology of China [2016YFA0500103]
The intermittent application of a FMD, with low carbohydrate/protein content and high dietary fiber, can reduce obesity and glucose intolerance induced by a high-fat high-sucrose diet in mice. It also decreases adipocyte size, increases expression of lipolysis genes and HSL protein in white adipose tissue, and reduces HFHSD-induced lipid accumulation in the liver. RNA sequencing shows elevated expression of genes involved in fatty acid oxidation with FMD intervention.
Scope Liver plays a central role in maintaining lipid homeostasis which is dysregulated in non-alcoholic fatty liver disease (NAFLD) caused by overload of dietary fat, increase in lipid synthesis, and alteration of fatty acid oxidation in the liver. In this study, we aimed to investigate whether intermittent calorie restriction using a fasting-mimicking diet (FMD) is able to slow down the progression of NAFLD in mice. Methods and Results This study analyzed the intervention activity of a FMD low in carbohydrate/protein but high in dietary fibers with a NAFLD mouse model induced by high-fat high-sucrose diet (HFHSD). Intermittent application of the FMD reduces HFHSD-induced obesity and glucose intolerance. The FMD decreases the size of adipocytes and elevates expression of lipolysis genes and HSL protein in white adipose tissue. HFHSD-induced lipid accumulation in the liver is reduced by the FMD, accompanied by a reduction of macrophage marker in the liver. RNA sequencing reveals that the expression of a number of genes involved in fatty acid oxidation is elevated by the FMD. Conclusion The findings indicate that intermittent application of the FMD can improve NAFLD, at least in part, through increased lipolysis in white adipose tissue and elevated fatty acid oxidation in the liver.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据