4.5 Article

Epsin 3 potentiates the NF-κB signaling pathway to regulate apoptosis in breast cancer

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Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to drive breast cancer dovelopment

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Summary: ER-negative breast cancer exhibits elevated NF-kappa B activity, and here it is shown that epsin proteins play a pivotal role in promoting breast cancer by promoting NEMO linear ubiquitination and sustaining NF-kappa B signaling. The heightened levels of epsins in ER-negative breast cancer are associated with poor relapse-free survival, and targeting epsins may represent a strategy to restrain NF-kappa B signaling and provide a new perspective into ER-negative breast cancer treatment.

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