4.7 Review

Role of long non-coding RNA H19 in the development of osteoporosis

期刊

MOLECULAR MEDICINE
卷 27, 期 1, 页码 -

出版社

SPRINGER
DOI: 10.1186/s10020-021-00386-0

关键词

Long noncoding RNA; lncRNA H19; Osteogenesis; Osteoporosis

资金

  1. National Natural Science Foundation of China [81972156]
  2. Natural Science Foundation of Liaoning Province [2019-ZD-0781]
  3. 345 Talent Project

向作者/读者索取更多资源

Research on the targeting of lncRNA H19 in the treatment of osteoporosis shows promising prospects due to its effects on osteogenic differentiation processes. This review summarizes the molecular pathways and mechanisms of lncRNA H19 in the pathogenesis of osteoporosis and the progress of research on targeting H19 as a treatment option, indicating emerging possibilities for more effective treatments for bone metabolism diseases with molecular targets.
Background Osteoporosis is a widespread and serious metabolic bone disease. At present, revealing the molecular mechanisms of osteoporosis and developing effective prevention and treatment methods are of great significance to health worldwide. LncRNA is a non-coding RNA peptide chain with more than 200 nucleotides. Researchers have identified many lncRNAs implicated in the development of diseases and lncRNA H19 is an example. Results A large amount of evidence supports the fact that long non-coding RNA (lncRNA) genes, such as H19, have multiple, far-reaching effects on various biological functions. It has been found that lncRNA H19 has a role in the regulation of different types of cells in the body including the osteoblasts, osteocytes, and osteoclasts found in bones. Therefore, it can be postulated that lncRNA H19 affects the incidence and development of osteoporosis. Conclusion The prospect of targeting lncRNA H19 in the treatment of osteoporosis is promising because of the effects that lncRNA H19 has on the process of osteogenic differentiation. In this review, we summarize the molecular pathways and mechanisms of lncRNA H19 in the pathogenesis of osteoporosis and summarize the research progress of targeting H19 as a treatment option. Research is emerging that explores more effective treatment possibilities for bone metabolism diseases using molecular targets.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据