Regulation of dendritic cell function by Fc-γ-receptors and the neonatal Fc receptor

Dendritic cells (DCs) express receptors to sense pathogens and/or tissue damage and to communicate with other immune cells. Among those receptors, Fc receptors (FcRs) are triggered by the Fc region of antibodies produced during adaptive immunity. In this review, the role of Fc gamma R and neonatal Fc receptor (FcRn) in DC immunity will be discussed. Their expression in DC subsets and impact on antigen uptake and presentation, DC maturation and polarisation of T cell responses will be described. Lastly, we will discuss the importance of FcR-mediated DC function in the context of immunity during viral infection, inflammatory disease, cancer and immunotherapy.

Automated summary

Dendritic cells (DCs) express receptors to sense pathogens and communicate with other immune cells. Fc receptors (FcRs) play a crucial role in DC immunity, affecting antigen uptake, presentation, DC maturation, and polarization of T cell responses.