4.4 Article

Feasible and clinical relevant outcome measures for adults with mitochondrial disease

期刊

MOLECULAR GENETICS AND METABOLISM
卷 135, 期 1, 页码 102-108

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymgme.2021.12.010

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Mitochondrial disease; Adults; Outcome measures; Physical therapy

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There is no consensus on suitable clinical outcome measures for adults with mitochondrial diseases. This study aimed to determine feasible and clinically relevant outcome measures for MD patients. The results showed that balance tests were feasible and significantly correlated with disease severity. However, the feasibility of the angstrom strand cycle test and the 6 min walking test in MD patients is unclear.
There is no consensus on clinical outcome measures that reflect function, activities and participation which are suitable for adults with mitochondrial diseases (MD). The aim of this study was to determine feasible and clinically relevant outcome measures for patients with MD . In 156 adult patients with MD, endurance, balance, strength and mobility tests were evaluated. All tests showed a negative deviation to healthy reference values. Balance tests were feasible and significantly correlated with clinical severity. The angstrom strand cycle test was not feasible in 55%, whereas the feasibility of the 6 min walking test is unclear in patients with MD. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).

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