Therapeutic potential of pyrrole and pyrrolidine analogs: an update

The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its diverse biological and medicinal importance. Biomolecules such as chlorophyll, hemoglobin, myoglobin, and cytochrome are naturally occurring metal complexes of pyrrole. These metal complexes play a vital role in a living system like photosynthesis, oxygen carrier, as well storage, and redox cycling reactions. Apart from this, many medicinal drugs are derived from either pyrrole, pyrrolidine, or by its fused analogs. This review mainly focuses on the therapeutic potential of pyrrole, pyrrolidine, and its fused analogs, more specifically anticancer, anti-inflammatory, antiviral, and antituberculosis. Further, this review summarizes more recent reports on the pyrrole, pyrrolidine analogs, and their biological potential. [GRAPHICS] .

Automated summary

The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been extensively studied due to their diverse biological and medicinal importance. Metal complexes of pyrrole, such as chlorophyll, hemoglobin, myoglobin, and cytochrome, play vital roles in living systems. Additionally, many medicinal drugs are derived from pyrrole, pyrrolidine, or their fused analogs. This review focuses on the therapeutic potential of pyrrole and pyrrolidine, particularly in anticancer, anti-inflammatory, antiviral, and antituberculosis applications. It also summarizes recent reports on pyrrole and pyrrolidine analogs and their biological potential.