期刊
MOLECULAR DIVERSITY
卷 26, 期 4, 页码 2269-2293出版社
SPRINGER
DOI: 10.1007/s11030-021-10333-0
关键词
N-[3-(benzimidazol-2-yl-amino)phenyl]amine; Flow cytometry; Cytotoxicity; National Cancer Institute; Anticancer agents
类别
资金
- NCT Delhi Government
This study reported the design, synthesis, and cytotoxicity studies of a series of derivatives, with two compounds showing remarkable cytotoxicity and inducing cell cycle arrest and apoptosis in leukemia cancer cells.
In this contribution, we report the design, synthesis and cytotoxicity studies of a series of N-[3-(benzimidazol-2-yl-amino)phenyl]amine and N-[3-(benzoxazol-2-ylamino)phenyl]amine derivatives. In vitro cytotoxicity assay of 26 selected compounds was carried out at National Cancer Institute (NCI), USA. Out of them, compounds 10e (NSC D-762842/1) and 11s (NSC D-764942/1) have shown remarkable cytotoxicity with GI(50) values ranging between 0.589-14.3 mu M and 0.276-12.3 mu M, respectively, in the representative nine subpanels of human tumor cell lines. Further, flow cytometry analysis demonstrated that compound 10e exerted cell cycle arrest at G2/M phase and showed dose-dependent enhancement in apoptosis in K-562 leukemia cancer cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据