Anti-inflammatory cytokines in sickle cell disease

Sickle cell disease (SCD) is a well-studied monogenetic disease with an established chronic inflammatory component. The paradigm shift towards inflammation has made the pathophysiology of SCD even more complex. Studies have shown that an imbalance between the pro-inflammatory and anti-inflammatory cytokines in SCD exists; however, the reports are skewed toward the pro-inflammatory mediators. We enumerate recent in vitro and in vivo studies on anti-inflammatory cytokines in SCD patients, and discuss the biology of anti-inflammatory cytokines including the already reported IL-2, TGF-beta, and IL-10 as well as the recently discovered IL-27, IL-35 and IL-37. This review will improve the understanding of the pathophysiology of SCD and aid in the search of new therapeutic options for patients with SCD.

Automated summary

Sickle cell disease is a well-studied monogenetic disease characterized by chronic inflammation. Recent studies have shown an imbalance between pro-inflammatory and anti-inflammatory cytokines in patients with sickle cell disease. This review improves understanding of the pathophysiology of the disease and offers insights for the development of new therapeutic options.