Molecular study of the proliferation process of beta cells derived from pluripotent stem cells

Background Diabetes mellitus (DM) is a chronic metabolic disorder, increasing in the number of patients and poses a severe threat to human health. Significant advances have been made in DM treatment; the most important of which is differentiation and proliferation of beta cells from IPSCs. Methods Data were collected from PUBMED at various time points up to the academic year of 2020. The related keywords are listed as follows: Induced pluripotent stem cell, Proliferation, Growth factor, Small molecule, cardiotoxicity and Scaffold. Result The use of growth factors along with small molecules can be a good strategy for beta-cell proliferation. Also, proliferation of beta cells on nanofibers scaffolds can create a similar in vivo environment, that leads to increased function of beta-cell. Some transcription factors that cause beta cells proliferation play an important role in inflammation; so, it is essential to monitor them to prevent inflammation. Conclusion Finally, the simultaneous use of growth factors, micronutrients and scaffolds can be an excellent strategy to increase the proliferation and function of beta cells derived from IPSCs.

Automated summary

Diabetes mellitus is a chronic metabolic disorder, and a significant advancement in treatment is the differentiation and proliferation of beta cells from induced pluripotent stem cells. Studies suggest that a combination of growth factors and small molecules can promote beta-cell proliferation, while proliferation of beta cells on nanofibers scaffolds can enhance beta-cell function by creating a similar in vivo environment.