期刊
MOLECULAR BIOLOGY OF THE CELL
卷 33, 期 2, 页码 -出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E21-08-0400
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资金
- NIH [GM107026]
This article reviews the current understanding of the formation of a bipolar spindle and discusses the self-organizing process involved. The potential future research directions in understanding the bipolar spindle are also explored.
Formation of a bipolar spindle is required for the faithful segregation of chromosomes during cell division. Twenty-five years ago, a transformative insight into how bipolarity is achieved was provided by Rebecca Heald, Eric Karsenti, and colleagues in their landmark publication characterizing a chromatin-mediated spindle assembly pathway in which centrosomes and kinetochores were dispensable. The discovery revealed that bipolar spindle assembly is a self-organizing process where microtubules, which possess an intrinsic polarity, polymerize around chromatin and become sorted by mitotic motors into a bipolar structure. On the 25th anniversary of this seminal paper, we discuss what was known before, what we have learned since, and what may lie ahead in understanding the bipolar spindle.
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