期刊
MOLECULAR BIOLOGY OF THE CELL
卷 32, 期 20, 页码 -出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E21-06-0305
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资金
- Boettcher Foundation
- American Cancer Society [RSG-16-157-01CCG]
- National Institute of General Medical Sciences [R01GM099820, R01GM132132]
Transcriptional control of centriole assembly is crucial for cell division, intracellular trafficking, and cilia. RNA splicing factor SON is specifically required for procentriole assembly by regulating the splicing and expression of genes involved in the microtubule cytoskeleton, centrosome, and centriolar satellites. Additionally, SON plays a key role in the proper splicing and expression of CEP131, which is essential for organizing the trafficking and MT network around centrosomes.
Control of centrosome assembly is critical for cell division, intracellular trafficking, and cilia. Regulation of centrosome number occurs through the precise duplication of centrioles that reside in centrosomes. Here we explored transcriptional control of centriole assembly and find that the RNA splicing factor SON is specifically required for completing procentriole assembly. Whole genome mRNA sequencing identified genes whose splicing and expression are affected by the reduction of SON, with an enrichment in genes involved in the microtubule (MT) cytoskeleton, centrosome, and centriolar satellites. SON is required for the proper splicing and expression of CEP131, which encodes a major centriolar satellite protein and is required to organize the trafficking and MT network around the centrosomes. This study highlights the importance of the distinct MT trafficking network that is intimately associated with nascent centrioles and is responsible for procentriole development and efficient ciliogenesis.
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