期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 477, 期 2, 页码 417-430出版社
SPRINGER
DOI: 10.1007/s11010-021-04286-z
关键词
circRNA; microRNA; m6A modification; Cardiovascular diseases
类别
资金
- National Natural Science Foundation of China [82070314, 81770275]
- Key Research and Development Project of Shandong Province [2017GSF18127]
- Taishan Scholar Program of Shandong Province
circRNAs are a novel class of RNA with closed-loop structures, functioning as sponges for microRNAs and playing important regulatory roles in the development of cardiovascular diseases.
Circular RNAs (circRNAs), a novel class of endogenous noncoding RNA, are characterized by their covalently closed-loop structures without a 5 ' cap or a 3 ' poly(A) tail. With the evolution of high-throughput sequencing technology and bioinformatics, an increasing number of circRNAs have been discovered, and their functions were highlighted. Cardiovascular diseases (CVDs) have become the world's leading killers, with serious impacts on human health. Although significant progress has been made in clarifying the development of CVDs from the molecular to the cellular level, CVDs remain one of the leading causes of death in humans. circRNAs mainly function as a sponge to absorb microRNAs, which results in the positive control of downstream proteins. They play important regulatory roles in the development of CVDs. This paper reviews current knowledge on the biogenesis, detection and validation, translation, translocation and degradation, and general functions of circRNAs, with a focus on their roles in CVDs.
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