期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 477, 期 1, 页码 255-265出版社
SPRINGER
DOI: 10.1007/s11010-021-04278-z
关键词
Diabetic cardiomyopathy; Hydrogen sulfide; Myocardial metabolism; Myocardial function; Exosome
类别
资金
- National Key Research and Development Program of China [2019YFA0801601]
- National Natural Science Foundation of China [81670429, 91839103]
- International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province [2018WK4031]
- Special Funding for Construction of Innovative Provinces in Hunan Province [2020SK2105]
- Double First-Class project for innovative Group of Basic Medicine, University of South China
Diabetic cardiomyopathy is a cardiovascular complication related to diabetes, obesity, or insulin resistance, characterized by metabolic disorders in cardiac tissues leading to heart dysfunction. Studies suggest that hydrogen sulfide may have therapeutic effects on diabetic cardiomyopathy by regulating cell metabolism and protecting cardiomyocytes.
Diabetic cardiomyopathy (DCM) is a cardiovascular complication that tends to occur in patients with diabetes, obesity, or insulin resistance, with a higher late mortality rate. Sustained hyperglycemia, increased free fatty acids, or insulin resistance induces metabolic disorders in cardiac tissues and cells, leading to myocardial fibrosis, left ventricular hypertrophy, diastolic and/or systolic dysfunction, and finally develop into congestive heart failure. The close connection between all signaling pathways and the complex pathogenesis of DCM cause difficulties in finding effective targets for the treatment of DCM. It reported that hydrogen sulfide (H2S) could regulate cell energy substrate metabolism, reduce insulin resistance, protect cardiomyocytes, and improve myocardial function by acting on related key proteins such as differentiation cluster 36 (CD36) and glucose transporter 4 (GLUT4). In this article, the relative mechanisms of H2S in alleviating metabolic disorders of DCM were reviewed, and how H2S can better prevent and treat DCM in clinical practice will be discussed.
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