期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 477, 期 5, 页码 1453-1461出版社
SPRINGER
DOI: 10.1007/s11010-021-04327-7
关键词
Ferroptosis; Glutathione peroxidase 4; Lipid peroxidation; Acute lung injury
类别
资金
- National Natural Science Foundation of China [82000082]
- Natural Science Foundation Of Anhui Province [2008085QH353]
- Fundamental Research Funds for the Central University [WK9110000124]
This review summarizes the recent discoveries on the role of ferroptosis in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) to provide new strategies for its prevention and treatment.
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a common disease with high morbidity and mortality, and its pathogenesis is believed to be related to oxidative stress, apoptosis, inflammation, and hypoxia. Ferroptosis is a type of nonapoptotic cell death characterized by iron-dependent lipid peroxide accumulation and is involved in many cellular physiological processes. Recent studies have confirmed that ferroptosis may be involved in the development of ALI. This review summarizes the most recent discoveries on the role of ferroptosis in ALI to provide new strategies for its prevention and treatment.
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