期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 247, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.molbiopara.2021.111431
关键词
Pomacea canaliculata; Angiostrongylus cantonensis; Proteomics; Molluscicide; Invasive species
资金
- National Natural Science Foundation of China [82072309]
- Clinical Research Project of Healthcare Industry of Shanghai Municipal Health Commission [202040054]
PBQ is a highly effective molluscicide with potent lethality against Pomacea canaliculata, affecting snail mortality by inhibiting protein synthesis pathways. Controlling Pomacea canaliculata can help prevent the transmission of Angiostrongylus cantonensis.
Angiostrongylus cantonensis is a zoonotic parasitic nematode that is the most common cause of human eosinophilic meningitis. The invasive apple snail Pomacea canaliculata is an important intermediate host of A. cantonensis and contributes to its spread. P. canaliculata control will help prevent its invasion and transmission of A. cantonensis. The new molluscicide PBQ (1-(4-chlorophenyl)-3-(pyridin-3-yl)urea) exhibits great potency against P. canaliculata and has low toxicity against mammals and non-target aquatic organisms. We studied the mode of action of PBQ using TMT-based comparative quantitative proteomics analysis between PBQ-treated and control P. canaliculata snails. A total of 3151 proteins were identified, and 245 of these proteins were significantly differentially expressed with 135 downregulated and 110 upregulated. GO and KEGG enrichment analyses identified GO terms and KEGG pathways involved in de novo purine biosynthesis, ribosome components and translation process were significantly enriched and downregulated. The results indicated that PBQ treatment had substantial effects on the synthesis of genetic material, translation process, and protein synthesis of P. canaliculata and were likely the main cause of snail mortality.
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