期刊
MITOCHONDRION
卷 62, 期 -, 页码 151-158出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2021.12.001
关键词
Adenosine triphosphate; Mitochondria; Programmed cell death protein-1; T cell
This article provides an overview of the potential predictive factors of PD-1 blockade in oncology and emphasizes the crucial role of mitochondria in response to anti-PD 1 therapies.
Immunotherapy based on programmed cell death protein-1 (PD-1) is a promising approach in oncology. However, a significant fraction of patients remain unresponsive. Therefore, it is imperative to clarify the relevant predictive factors. A decrease in cellular adenosine triphosphate (c-ATP) level can predispose to cellular dysfunction. ATP is a prerequisite for proper T cell migration and activation. Therefore, a decrease in the c-ATP level impairs T cell function and promotes cancer progression. This article gives an overview of the potential predictive factors of PD-1 blockade. Besides, it highlights the pivotal role of mitochondria in response to anti-PD 1 therapies.
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