Introduction of Fe into mesoporous MCM-41 for the synthesis of 5-substituted 1H-Tetrazoles from aryl nitriles in water

In this exploration, new recyclable mesoporous-supported iron particles with the ligand and without ligand (MCM-41@ 3,4,5-tri hydroxyphenyl acetic acid @Fe and MCM-41@Fe) have been developed through post-functionalization modification of silica MCM-41. These catalysts were demonstrated to be novel, effective, and green for the synthesis of 5-substituted H-1-tetrazoles from aryl nitriles in water. In these systems, 5-substituted H-1-tetrazoles are produced as the only product. Fe3+ species were identified as active sites. The ordered mesoporous iron-silica catalyst with the ligand displayed better catalytic activity compared to iron-silica catalyst without the ligand, which was ascribed to the improvement of the inter-action of iron with the support. The catalysts can be easily separated using simple recovery and reused several times with consistent activity.

Automated summary

Novel recyclable mesoporous-supported iron particles with and without ligands were developed for the synthesis of 5-substituted H-1-tetrazoles from aryl nitriles in water. Fe3+ species were identified as active sites, with the ligand-supported catalyst displaying better catalytic activity due to improved interaction with the support. The catalysts can be easily separated, recovered, and reused multiple times with consistent activity.