Characterization of red blood cell deformability induced by acoustic radiation force

A cyclic coupling computational model is developed to investigate the large deformation of swollen red blood cells (RBCs) induced by the acoustic radiation force arising from an ultrasonic standing wave field. The RBC consists of an internal fluid enclosed by a thin elastic membrane. Based on the acoustic radiation stress tensor theory, the acoustic radiation force exerted on the cell membrane is calculated. A continuum mechanical theory is adopted to model the mechanical response of the membrane, which is capable of accounting for the in-plane and bending deformation of the cell membrane. The cyclic coupling computation of the acoustic fields and mechanical deformation is realized in a finite element model. With the developed model, the acoustic deformation of a single cell is calculated and results are compared with the semi-analytical solutions for validation purposes. Then, the multiple cell deformation is considered, showing that the multiple cell deformation is influenced by the secondary acoustic radiation force arising due to cell-cell interaction. This work provides an accurate numerical approach to predict the acoustic deformability of cells, which might help explore the application of the ultrasonic technique in disease diagnosis and in promoting stem cell differentiation.

Automated summary

A cyclic coupling computational model is developed to investigate the large deformation of swollen red blood cells induced by the acoustic radiation force. The model accurately predicts the acoustic deformability of cells by calculating the acoustic radiation force and mechanical response of the cell membrane. The results also demonstrate that the deformation of multiple cells is influenced by cell-cell interaction.