期刊
MICROCHEMICAL JOURNAL
卷 169, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.microc.2021.106598
关键词
Cardiac troponin I; Electrochemical aptasensor; Copper nanowires; Molybdenum disulfide; Reduced graphene oxide
资金
- National Natural Science Foundation of China [21775095, 21707082]
- Shanxi Hundred Talent Pro-gram
- Scientific and Technological Key Project of Shanxi Prov-ince [20191102005]
In this study, an electrochemical aptasensor was developed for the detection of cTnI using CuNWs/MoS2/rGO structure, showing excellent detection performance with a wide linear range and low detection limit. The sensor demonstrated good selectivity, stability, and reproducibility, making it applicable for cTnI analysis in human blood samples.
Cardiac troponin I (cTnI) is a gold standard biomarker for clinical diagnose of acute myocardial infarction (AMI). Rapid, accurate, and sensitive detection methods for cTnI are highly urgent and significant in early diagnosis and progression control. In this work, we proposed an electrochemical aptasensing platform for cTnI detection based on copper nanowires/molybdenum disulfide/reduced graphene oxide (CuNWs/MoS2/rGO) ternary nanostructure. The CuNWs/MoS2/rGO composite exhibited improved electrochemical activity due to the high electrochemical conductivity and the synergistic effect among each component, and the large surface area, which also facilitates the immobilization of aptamers. As a result, the constructed electrochemical cTnI aptasensor shows good selectivity, stability, and reproducibility towards cTnI. Under optimized conditions, the aptasensor responses cTnI linearly from 5.0 x 10(-13) to 1.0 x 10(-10) g mL(-1) with a detection limit of 1.0 x 10(-13) g mL(-1) (S/N = 3). The analysis of cTnI in human blood samples demonstrated its practicability with comparable results. This work offers an alternative way for facile fabrication of CuNWs/MoS2/rGO based aptasensor for clinical biomarker detection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据