期刊
MICROCHEMICAL JOURNAL
卷 170, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.microc.2021.106686
关键词
Hydrophobic deep eutectic solvent; Non-steroidal anti-inflammatory drugs; Dispersive liquid-liquid microextraction; High-performance liquid chromatography
资金
- Fundamental Research Funds for the Central Universities [DUT18RC (4) 058]
In this study, novel and natural hydrophobic deep eutectic solvents (HDESs) were prepared and used for the analysis of NSAIDs through the UA-DLLME method combined with HPLC. Multiple extraction parameters were optimized, resulting in good sensitivity and recoveries. The method was successfully applied to real samples.
In the present study, several novel and natural hydrophobic deep eutectic solvents (HDESs) were prepared, and one of the HDESs composed of guanidinium chloride and thymol was advantageously used to develop an ultrasound-assisted dispersive liquid-liquid microextraction (UA-DLLME) method combined with high-performance liquid chromatography for the determination of four non-steroidal anti-inflammatory drugs (NSAIDs). Several important parameters influencing extraction efficiency were investigated and optimized, including the type and volume of HDES, ultrasound time, solution pH and the amount of salt addition. Under optimal experimental conditions, the method showed good linearity with the determination coefficients (R-2) of 0.994-0.999 in the linear range of 5-2000 mu g/L, low limits of detection of 0.5-1 mu g/L and acceptable recoveries in the range of 79.42%-107.52%. The proposed method was successfully applied for the pretreatment of trace NSAIDs in real water and milk samples, and the results demonstrated the potential of the synthesized HDES for the extraction and determination of contaminants in aqueous samples.
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