4.5 Article

Transcriptome analysis of host response to porcine epidemic diarrhea virus nsp15 in IPEC-J2 cells

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Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication

Bo Gao et al.

Summary: Coronaviruses use the endoribonuclease nsp15 to interfere with the formation of anti-viral stress granules (SGs), reducing viral dsRNA accumulation and antagonizing PKR activation, thereby ensuring productive virus replication. Nsp15s from various coronaviruses interfere with SGs formation, possibly by targeting essential SGs assembly factors, indicating a conserved mechanism among coronaviruses to counteract host antiviral responses. This study highlights the role of nsp15 in suppressing the integral stress response and crosstalk with anti-innate immune response.

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