Comparative Host-Pathogen Interaction Analyses of SARS-CoV2 and Aspergillus fumigatus, and Pathogenesis of COVID-19-Associated Aspergillosis

Article Immunology

Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study

Michele Bartoletti et al.

Summary: The study showed a high incidence of CAPA among critically ill COVID-19 patients, and its occurrence seems to alter the natural course of the disease.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Biochemical Research Methods

Comparative host-pathogen protein-protein interaction analysis of recent coronavirus outbreaks and important host targets identification

Abdul Arif Khan et al.

Summary: Coronavirus outbreaks, including SARS, MERS and COVID-19, have caused significant global healthcare and economic burdens in the past two decades. Efforts to identify potential viral targets for management of these outbreaks are ongoing, with a focus on common host proteins to prevent current and future outbreaks. Targeting proteins like FURIN and TMPRSS2, which are involved in recent and previous outbreaks, may provide promising results in the development of new therapeutic modalities. However, safety evaluation and risk assessment are crucial considerations when targeting necessary human proteins for the management of coronavirus.

BRIEFINGS IN BIOINFORMATICS (2021)

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Review Biochemistry & Molecular Biology

Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?

Simone Cristina Soares Brandao et al.

Summary: The severe form of COVID-19 is characterized by an abnormal and exacerbated immune response, especially in patients with obesity, diabetes, hypertension, and atherosclerosis. The virus spike protein interacts strongly with TLR4, leading to a cytokine storm and multiple organ failure in some cases.

CYTOKINE & GROWTH FACTOR REVIEWS (2021)

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Review Immunology

COVID-19 associated with pulmonary aspergillosis: A literature review

Chih-Cheng Lai et al.

Summary: Co-infections of Aspergillus spp. in patients with COVID-19, especially in severe/critical cases, have been reported with incidence ranging from 19.6% to 33.3%. Acute respiratory distress syndrome and high mortality rates are common complications, while early diagnosis through fungus culture and galactomannan testing is crucial for appropriate management. Vigilance and aggressive microbiological studies are recommended for severe/critical COVID-19 patients to detect pulmonary aspergillosis promptly.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2021)

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Article Biochemistry & Molecular Biology

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions

Rose Oughtred et al.

Summary: BioGRID is an open-access database resource that houses protein and genetic interactions from multiple species, serving as a tool for building complex networks to facilitate biomedical discoveries. Curated from primary experimental evidence, BioGRID captures both low-throughput and large high-throughput studies, including protein post-translational modifications and interactions with bioactive small molecules. Additionally, it undertakes themed curation projects in specific aspects of cellular regulation and disease areas.

PROTEIN SCIENCE (2021)

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Article Gastroenterology & Hepatology

Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

Yun Kit Yeoh et al.

Summary: This study found that the gut microbiome composition was significantly altered in patients with COVID-19 compared to non-COVID-19 individuals, regardless of medication received. Certain gut commensals known for their immunomodulatory potential were underrepresented in patients and remained low even after disease resolution. Additionally, the altered gut microbiome composition correlated with disease severity and elevated levels of inflammatory cytokines and blood markers.

GUT (2021)

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Review Dermatology

Invasive pulmonary aspergillosis in the COVID-19 era: An expected new entity

Marina Machado et al.

Summary: COVID-19-associated pulmonary aspergillosis is a serious and potentially life-threatening complication in severe COVID-19 patients, especially those receiving corticosteroids. Mortality rate in reviewed cases is high at 56.3%.

MYCOSES (2021)

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Article Immunology

Invasive pulmonary aspergillosis associated with COVID-19 in a kidney transplant recipient

Hernando Trujillo et al.

Summary: This case describes a kidney transplant recipient with severe COVID-19 who was subsequently diagnosed with probable IPA, with favorable outcomes after treatment.

TRANSPLANT INFECTIOUS DISEASE (2021)

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Article Immunology

Salmonella enterica subsp. enterica host-pathogen interactions and their implications in gallbladder cancer

Abdul Arif Khan et al.

Summary: The study found that Salmonella interacts with multiple human proteins involved in gallbladder carcinoma, with MAPK and RAC1 being the most important based on node degree value among all identified interactors. Functional over-representation analysis reveals that Salmonella can induce adenocarcinoma, which constitutes 85% of gallbladder cancer.

MICROBIAL PATHOGENESIS (2021)

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Article Immunology

COVID-19-Associated Pulmonary Aspergillosis, March-August 2020

Jon Salmanton-Garcia et al.

Summary: This study found that most patients with coronavirus disease-associated pulmonary aspergillosis (CAPA) are diagnosed shortly after admission, with the majority being treated in the ICU. Azole-resistant strains of Aspergillus fumigatus were common in patients, and voriconazole was the main treatment choice. The overall mortality rate was approximately 52.2%, with about one third of deaths attributed to CAPA.

EMERGING INFECTIOUS DISEASES (2021)

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Article Medicine, Research & Experimental

Invasive pulmonary aspergillosis complicating COVID-19 in the ICU - A case report

Juergen Prattes et al.

Summary: It is uncertain whether critically ill COVID-19 patients are more susceptible to fungal infections. However, a case report has shown that invasive pulmonary aspergillosis (IPA) can occur in such patients even without typical risk factors.

MEDICAL MYCOLOGY CASE REPORTS (2021)

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Letter Critical Care Medicine

COVID-19-associated Pulmonary Aspergillosis

Andreas L. E. van Arkel et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Article Biochemical Research Methods

COVID-2019-associated overexpressed Prevotella proteins mediated host-pathogen interactions and their role in coronavirus outbreak

Abdul Arif Khan et al.

BIOINFORMATICS (2020)

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Article Microbiology

Protein-protein interactions of HPV-Chlamydia trachomatis-human and their potential in cervical cancer

Abdul Arif Khan et al.

FUTURE MICROBIOLOGY (2020)

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Article Gastroenterology & Hepatology

Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization

Tao Zuo et al.

GASTROENTEROLOGY (2020)

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Editorial Material Public, Environmental & Occupational Health

Invasive pulmonary aspergillosis complicating SARS-CoV-2 pneumonia: A diagnostic challenge

Spinello Antinori et al.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2020)

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Letter Critical Care Medicine

COVID-19-associated invasive pulmonary aspergillosis

Lynn Rutsaert et al.

ANNALS OF INTENSIVE CARE (2020)

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Letter Critical Care Medicine

Prevalence of putative invasive pulmonary aspergillosis in critically ill patients with COVID-19

Alexandre Alanio et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Dermatology

COVID-19 associated pulmonary aspergillosis

Philipp Koehler et al.

MYCOSES (2020)

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Editorial Material Respiratory System

Confronting and mitigating the risk of COVID-19 associated pulmonary aspergillosis

Darius Armstrong-James et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Review Immunology

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

Bingwen Liu et al.

JOURNAL OF AUTOIMMUNITY (2020)

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Article Virology

Co-infection with respiratory pathogens among COVID-2019 cases

Xiaojuan Zhu et al.

VIRUS RESEARCH (2020)

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Article Medicine, Research & Experimental

Ac2-26 mimetic peptide of annexin A1 to treat severe COVID-19: A hypothesis

Andre Gustavo Bonavita

MEDICAL HYPOTHESES (2020)

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Article Dermatology

Putative invasive pulmonary aspergillosis in critically ill patients with COVID-19: An observational study from New York City

Hayato Mitaka et al.

MYCOSES (2020)

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Article Immunology

NF-κB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients

Ralf Kircheis et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

Covid-19-Associated Pulmonary Aspergillosis: The Other Side of the Coin

Claudio Costantini et al.

VACCINES (2020)

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Letter Immunology

Fatal Invasive Aspergillosis and Coronavirus Disease in an Immunocompetent Patient

Marion Blaize et al.

EMERGING INFECTIOUS DISEASES (2020)

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Letter Critical Care Medicine

Clinical characteristics of invasive pulmonary aspergillosis in patients with COVID-19 in Zhejiang, China: a retrospective case series

Jie Wang et al.

CRITICAL CARE (2020)

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Review Critical Care Medicine

Diagnosing invasive pulmonary aspergillosis in ICU patients: putting the puzzle together

Stijn Blot et al.

CURRENT OPINION IN CRITICAL CARE (2019)

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Article Microbiology

Kinetic host defense of the mice infected with Aspergillus Fumigatus

Huilin Su et al.

FUTURE MICROBIOLOGY (2019)

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Article Biochemical Research Methods

Inter-kingdom prediction certainty evaluation of protein subcellular localization tools: microbial pathogenesis approach for deciphering host microbe interaction

Abdul Arif Khan et al.

BRIEFINGS IN BIOINFORMATICS (2018)

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Review Respiratory System

Invasive pulmonary aspergillosis

E. Blanchard et al.

REVUE DES MALADIES RESPIRATOIRES (2018)

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Article Pediatrics

Invasive Aspergillosis

Bethany A. Darling et al.

PEDIATRICS IN REVIEW (2018)

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Article Multidisciplinary Sciences

Translational proteomic study to address host protein changes during aspergillosis

Guillaume Desoubeaux et al.

PLOS ONE (2018)

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Article Biochemistry & Molecular Biology

DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants

Janet Pinero et al.

NUCLEIC ACIDS RESEARCH (2017)

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Article Microbiology

Aspergillus fumigatus CalA binds to integrin α5β1 and mediates host cell invasion

Hong Liu et al.

NATURE MICROBIOLOGY (2017)

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Article Immunology

Invasive Aspergillosis Current Strategies for Diagnosis and Management

Jose Cadena et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2016)

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Article Mathematical & Computational Biology

HPIDB 2.0: a curated database for host-pathogen interactions

Mais G. Ammari et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2016)

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Article Biochemistry & Molecular Biology

Suppression of Epithelial Signal Transducer and Activator of Transcription 1 Activation by Extracts of Aspergillus fumigatus

Bharat Bhushan et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2015)

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Article Biochemical Research Methods

Prediction of host - pathogen protein interactions between Mycobacterium tuberculosis and Homo sapiens using sequence motifs

Tong Huo et al.

BMC BIOINFORMATICS (2015)

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Article Oncology

Computational prediction of Escherichia coli proteins host subcellular targeting and their implications in colorectal cancer etiology

Abdul Arif Khan et al.

CANCER LETTERS (2015)

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Article Microbiology

Host Biomarkers of Invasive Pulmonary Aspergillosis To Monitor Therapeutic Response

Mila Krel et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

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Article Biochemistry & Molecular Biology

BIPS: BIANA Interolog Prediction Server. A tool for protein-protein interaction inference

Javier Garcia-Garcia et al.

NUCLEIC ACIDS RESEARCH (2012)

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Article Immunology

Aspergillus fumigatus cell wall components differentially modulate host TLR2 and TLR4 responses

Louis Y. A. Chai et al.

MICROBES AND INFECTION (2011)

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Article Biochemical Research Methods

Biana: a software framework for compiling biological interactions and analyzing networks

Javier Garcia-Garcia et al.

BMC BIOINFORMATICS (2010)

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Article Biochemical Research Methods

Prediction of protein-protein interactions using distant conservation of sequence patterns and structure relationships

J Espadaler et al.

BIOINFORMATICS (2005)

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Letter Medicine, General & Internal

Fatal aspergillosis in a patient with SARS who was treated with corticosteroids

HJ Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

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Comparative Host-Pathogen Interaction Analyses of SARS-CoV2 and Aspergillus fumigatus, and Pathogenesis of COVID-19-Associated Aspergillosis

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