☆ 4.7 Review

Systematic review with meta-analysis of diagnostic test accuracy for COVID-19 by mass spectrometry

METABOLISM-CLINICAL AND EXPERIMENTAL (2022)

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Systematic review with meta-analysis of the accuracy of diagnostic tests for COVID-19

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Summary: This study systematically reviewed the accuracy parameters of different diagnostic methods for detecting SARS-CoV-2, finding that computed tomography has high sensitivity but low specificity, while the combination of IgM and IgG antibodies showed promising results. The research also indicated that RT-PCR remains the gold standard for diagnosing COVID-19 in sputum samples, but combining different diagnostic methods can improve accuracy.

AMERICAN JOURNAL OF INFECTION CONTROL (2021)

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Article Biophysics

COVID-19 diagnosis - A review of current methods

Meral Yuce et al.

Summary: A fast and accurate self-testing tool for COVID-19 diagnosis is crucial for understanding the global situation and taking appropriate actions. The diagnosis tools available mainly rely on viral gene detection, human antibody detection, and viral antigen detection, with RT-PCR being the most reliable technique.

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Article Chemistry, Analytical

Covid-19 Automated Diagnosis and Risk Assessment through Metabolomics and Machine Learning

Jeany Delafiori et al.

Summary: COVID-19 continues to pose a heavy burden worldwide, emphasizing the importance of patient screening and risk management. Our integration of machine learning algorithms with mass spectrometry led to the development of a rapid platform for distinguishing COVID-19 in plasma samples and providing tools for risk assessment, aiding in patient management and decision-making.

ANALYTICAL CHEMISTRY (2021)

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Article Medicine, General & Internal

Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study

Stanislas Grassin-Delyle et al.

Summary: This study characterized the exhaled breath from mechanically ventilated adults with COVID-19 using real-time proton transfer reaction time-of-flight mass spectrometry. The analysis was able to differentiate between COVID-19 and non-COVID-19 ARDS with high accuracy. Characteristic volatile compounds were identified in the exhaled breath of COVID-19 patients, showing potential for early diagnosis.

EBIOMEDICINE (2021)

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Article Biochemistry & Molecular Biology

Comprehensive Meta-Analysis of COVID-19 Global Metabolomics Datasets

Zhiqiang Pang et al.

Summary: This study conducted a comprehensive meta-analysis of global metabolomics datasets from three countries to identify key metabolic signatures characterizing COVID-19 disease progression and clinical outcomes, providing important insights for clinical care and therapeutics development.

METABOLITES (2021)

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Article Chemistry, Analytical

Rapid Detection of COVID-19 Using MALDI-TOF-Based Serum Peptidome Profiling

Ling Yan et al.

Summary: This study developed a high-throughput serum peptidome profiling method based on MALDI-TOF MS for efficient detection of COVID-19. With a logistic regression machine learning model consisting of 25 feature peaks, the highest accuracy (99%), sensitivity (98%), and specificity (100%) were achieved, showing great potential for screening, routine surveillance, and diagnosis of COVID-19 in large populations.

ANALYTICAL CHEMISTRY (2021)

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Editorial Material Infectious Diseases

Anticipating outcomes for patients with COVID-19 and identifying prognosis patterns

Michael Darmon et al.

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Article Endocrinology & Metabolism

The serum metabolome of COVID-19 patients is distinctive and predictive

Ding Shi et al.

Summary: The serum metabolome of COVID-19 patients is distinctive and can be used for investigating pathogenesis, determining a diagnosis, predicting severe cases, and improving treatment. Specific metabolites were found to distinguish COVID-19 patients from healthy controls and predict disease progression, with some being recovered after discharge.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Review Chemistry, Analytical

Mass spectrometry analytical responses to the SARS-CoV2 coronavirus in review

Justin H. Griffin et al.

Summary: This article discusses the various applications of mass spectrometry in response to the SARS-CoV2 coronavirus, such as detecting biomarkers, studying viral peptides, and analyzing peptides in clinical specimens, with advantages of rapidity, high sensitivity, high molecular precision, and high sample throughput.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2021)

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Article Multidisciplinary Sciences

Novel application of automated machine learning with MALDI-TOF-MS for rapid high-throughput screening of COVID-19: a proof of concept

Nam K. Tran et al.

Summary: ML-enhanced MALDI-TOF-MS for COVID-19 testing provides a performance-comparable solution that overcomes logistical barriers encountered by current testing paradigms.

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Article Medicine, General & Internal

Detection of SARS-CoV-2 Infection in Human Nasopharyngeal Samples by Combining MALDI-TOF MS and Artificial Intelligence

Meritxell Deulofeu et al.

Summary: The study developed a rapid and accurate diagnostic test for COVID-19 by combining MALDI-TOF MS analysis of NP samples with machine learning techniques. The best model showed high performance with accuracy, sensitivity, and specificity values exceeding 90%, making it a reliable method for early detection of the disease.

FRONTIERS IN MEDICINE (2021)

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Article Chemistry, Analytical

Rapid Screening of COVID-19 Directly from Clinical Nasopharyngeal Swabs Using the MasSpec Pen

Kyana Y. Garza et al.

Summary: This study introduces a new method for COVID-19 screening using the MasSpec Pen technology to analyze lipid profiles directly from nasopharyngeal swabs, enabling rapid and accurate differentiation of infected and non-infected individuals. The system requires minimal operating steps and no specialized reagents, representing a promising alternative high-throughput method for COVID-19 screening.

ANALYTICAL CHEMISTRY (2021)

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Editorial Material Immunology

The missing season: The impacts of the COVID-19 pandemic on influenza Comment

Casey M. Zipfel et al.

Summary: During the COVID-19 pandemic, the seasonal influenza was entirely suppressed, providing valuable lessons for the future control of respiratory diseases.

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Article Multidisciplinary Sciences

SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care

Clemens Gutmann et al.

Summary: Prognostic characteristics for ICU COVID-19 patients can be determined using blood samples, with RNAemia and pentraxin-3 identified as predictors of 28-day ICU mortality. Additionally, galectin-3-binding protein is found to interact with the SARS-CoV-2 spike glycoprotein and exhibit antiviral properties.

NATURE COMMUNICATIONS (2021)

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Article Medicine, General & Internal

A mass spectrometry-based targeted assay for detection of SARS-CoV-2 antigen from clinical specimens

Santosh Renuse et al.

Summary: The study developed a method to detect SARS-CoV-2 viral antigen from nasopharyngeal swab samples using immunoaffinity purification and high resolution mass spectrometry. The optimized assay showed 98% sensitivity and 100% specificity, demonstrating potential for clinical deployment in diagnostic laboratories.

EBIOMEDICINE (2021)

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Article Biochemistry & Molecular Biology

Diagnostic Potential of the Plasma Lipidome in Infectious Disease: Application to Acute SARS-CoV-2 Infection

Nicola Gray et al.

Summary: Using lipid profiling and multivariate modeling, a refined panel of discriminant features from different lipid subclasses was developed to effectively differentiate between SARS-CoV-2 infection, healthy controls, and non-SARS-CoV-2 respiratory infections. The analysis showed strong predictive power and potential for facilitating accurate diagnosis and clinical management of the virus.

METABOLITES (2021)

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Article Multidisciplinary Sciences

Multi-omics analysis of respiratory specimen characterizes baseline molecular determinants associated with SARS-CoV-2 outcome

Jaswinder Singh Maras et al.

Summary: The study found that increased basal levels of MX1 and WARS are correlated with SARS-CoV-2 infection and could help identify patients at higher risk of severity. Additionally, patients with COVID-19 showed increased immune activation, metabolic reprogramming, and decreased oxygen transport, indicating a complex immune response and physiological changes associated with the disease.

ISCIENCE (2021)

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Article Medical Laboratory Technology

MALDI-ToF protein profiling as a potential rapid diagnostic platform for COVID-19

Prajkta Chivte et al.

Summary: The study suggests saliva as a feasible specimen for early detection of SARS-CoV-2, and identified potential biomarker peaks with high concordance with COVID-19 positive individuals through MALDI-ToF mass spectrometry analysis.

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Diagnosis of COVID-19 by exhaled breath analysis using gas chromatography-mass spectrometry

Wadah Ibrahim et al.

Summary: The study aimed to evaluate the role of exhaled breath volatile biomarkers in identifying patients with suspected or confirmed COVID-19 infection. The results showed that GC-MS-detected exhaled breath biomarkers were able to identify PCR-positive COVID-19 patients. External replication of these compounds is needed to validate the results.

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Article Medicine, General & Internal

Changes to the sebum lipidome upon COVID-19 infection observed via rapid sampling from the skin

Matt Spick et al.

Summary: The study revealed lower lipid levels in COVID-19 positive patients, indicating dyslipidemia. Sebum sampling showed potential for distinguishing between COVID-19 positive and negative patients based on lipidomic analysis.

ECLINICALMEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Detection of SARS-CoV-2 in nasal swabs using MALDI-MS

Fabiane M. Nachtigall et al.

NATURE BIOTECHNOLOGY (2020)

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Torben Kimhofer et al.

JOURNAL OF PROTEOME RESEARCH (2020)

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Article Biochemical Research Methods

A combined approach of MALDI-TOF mass spectrometry and multivariate analysis as a potential tool for the detection of SARS-CoV-2 virus in nasopharyngeal swabs

Maria Florencia Rocca et al.

JOURNAL OF VIROLOGICAL METHODS (2020)

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Article Multidisciplinary Sciences

Establishing a mass spectrometry-based system for rapid detection of SARS-CoV-2 in large clinical sample cohorts

Karina Helena Morais Cardozo et al.

NATURE COMMUNICATIONS (2020)

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Article Medicine, General & Internal

Diagnosis of COVID-19 by analysis of breath with gas chromatography-ion mobility spectrometry - a feasibility study

Dorota M. Ruszkiewicz et al.

ECLINICALMEDICINE (2020)

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Review Medicine, General & Internal

Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies The PRISMA-DTA Statement

Matthew D. F. McInnes et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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Article Medicine, General & Internal

QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies

Penny F. Whiting et al.

ANNALS OF INTERNAL MEDICINE (2011)

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Article Health Care Sciences & Services

Undue reliance on I2 in assessing heterogeneity may mislead

Gerta Ruecker et al.

BMC MEDICAL RESEARCH METHODOLOGY (2008)

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Review Medicine, General & Internal

Cautionary tales in the clinical interpretation of studies of diagnostic tests

I. A. Scott et al.

INTERNAL MEDICINE JOURNAL (2008)

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Review Spectroscopy

Mass spectrometry-based omics technologies in cancer diagnostics

Xuewu Zhang et al.

MASS SPECTROMETRY REVIEWS (2007)

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Review Biotechnology & Applied Microbiology

Metabolomics by numbers: acquiring and understanding global metabolite data

R Goodacre et al.

TRENDS IN BIOTECHNOLOGY (2004)

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Article Medicine, General & Internal

Measuring inconsistency in meta-analyses

JPT Higgins et al.

BMJ-BRITISH MEDICAL JOURNAL (2003)

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