A reliable and automated synthesis of 6-[18F]fluoro-L-DOPA and the clinical application on the imaging of congenital hyperinsulinism of infants

6-[F-18]fluoro-L-DOPA is a radiotracer widely used in the diagnosis of a range of diseases, including neuro-oncology, endocrinology, and Parkinson's disease. To meet the rapidly growing clinical need for this radioactive compound, this study reports an optimized radiosynthesis for this molecule, which proved to be highly reliable and compatible with different types of automated radiosynthesizers. Moreover, with 6-[F-18]fluoro-L-DOPA, the PET/CT imaging of a total of 23 patients has been conducted, further demonstrating this radiotracer as a clinically valuable reagent to diagnose congenital hyperinsulinism (CHI) of infants in a non-invasive manner and, more importantly, localize the exact lesion on pancreas. [GRAPHICS] .

Automated summary

This study reports an optimized synthesis method for the radiotracer 6-[F-18]fluoro-L-DOPA, which is reliable and compatible with different types of automated radiosynthesizers. PET/CT imaging of 23 patients using this radiotracer demonstrated its clinical value in non-invasive diagnosis of congenital hyperinsulinism and localization of pancreatic lesions.