期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 199, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2021.111567
关键词
NAD(+); Alzheimer's disease; Ageing; Healthspan
资金
- Helse SOr-Ost [2017056, 2020001, 2021021]
- Research Council of Norway [262175, 277813]
- National Natural Science Foundation of China [81971327]
- Akershus University Hospital [269901, 261973]
- Civitan Norges Forskningsfond for Alzheimers sykdom [281931]
- Czech Republic-Norway KAPPA programme [TO01000215]
- Rosa slOyfe/Norwegian Cancer Society & Norwegian Breast Cancer So-ciety [207819]
- Swiss Federal Institute of Technology, Eidgenodssische Technische Hochschule Zurich ETH Zurich
NAD+ is a crucial molecule in human life and health, with age-related decline in cellular NAD+ levels. However, NAD+ precursor supplementation can potentially extend lifespan, mitigate diseases, and have therapeutic potential for aging-related conditions.
NAD+ is a fundamental molecule in human life and health as it participates in energy metabolism, cell signalling, mitochondrial homeostasis, and in dictating cell survival or death. Emerging evidence from preclinical and human studies indicates an age-dependent reduction of cellular NAD+, possibly due to reduced synthesis and increased consumption. In preclinical models, NAD+ repletion extends healthspan and / or lifespan and mitigates several conditions, such as premature ageing diseases and neurodegenerative diseases. These findings suggest that NAD+ replenishment through NAD+ precursors has great potential as a therapeutic target for ageing and age-predisposed diseases, such as Alzheimer's disease. Here, we provide an updated review on the biological activity, safety, and possible side effects of NAD+ precursors in preclinical and clinical studies. Major NAD+ precursors focused on by this review are nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), and the new discovered dihydronicotinamide riboside (NRH). In summary, NAD+ precursors have an exciting therapeutic potential for ageing, metabolic and neurodegenerative diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据