期刊
BIOMATERIALS ADVANCES
卷 134, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.msec.2021.112559
关键词
Conducting polymer; Hydrogel; Polypyrrole; Biomaterials; Stimuli-responsive materials
资金
- Marsden Fund Council
- Rutherford Discovery Fellowship from Government
This study investigates the properties of stimuli-responsive hydrogels containing conducting polymers under different temperatures and electrochemical stimulation. The results show significant changes in the Young's modulus and actuation of the hybrid hydrogel at the transition temperature, as well as demonstrated cell adhesion to the hybrid hydrogel.
Hydrogels are a popular substrate for cell culture due to their mechanical properties closely resembling natural tissue. Stimuli-responsive hydrogels are a good platform for studying cell response to dynamic stimuli. Poly(N-isopropylacrylamide) (pNIPAM) is a thermo-responsive polymer that undergoes a volume-phase transition when heated to 32 ??C. Conducting polymers can be incorporated into hydrogels to introduce electrically responsive properties. The conducting polymer, polypyrrole (PPy), has been widely studied as electrochemical actuators due to its electrochemical stability, fast actuation and high strains. We determine the volume-phase transition temperature of pNIPAM hydrogels with PPy electropolymerised with different salts as a film within the hydrogel network. We also investigate the electro-mechanical properties at the transition temperature (32 ??C) and physiological temperature (37 ??C). We show statistically significant differences in the Young's modulus of the hybrid hydrogel at elevated temperatures upon electrochemical stimulation, with a 5 kPa difference at the transition temperature. Furthermore, we show a three-fold increase in actuation at transition temperature compared to room temperature and physiological temperature, attributed to the movement of ions in/out of the PPy film that induce the volume-phase transition of the pNIPAM hydrogel. Furthermore, cell adhesion to the hybrid hydrogel was demonstrated with mouse articular chondrocytes.
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