期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2021.112422
关键词
Hydrogel; Triple-network; Adhesive; Hemostasis; Antibacterial
资金
- National Natural Science Foundation of China [81972904]
- Key Program for BasicResearch of Shanghai [19JC1415600]
- Shanghai Rising-Star Pro-gram [20QA1407200]
- Shanghai Sailing Program [20YF1448400]
- Naval Medical University Sailing Program [2019-QH-16]
- Shanghai Changhai Hospital Youth Found [2019-QH-16]
The study developed a novel hemostatic hydrogel with a unique structure, capable of withstanding high blood pressure and exhibiting excellent hemostatic effects and biocompatibility, providing a new design approach for hemostasis and wound healing.
An in-situ formed hemostatic hydrogel (GelMA/OD/Borax) was prepared for the emergency wound hemostasis and anti-inflammation applications. Gelatin was chosen as the backbone and modified with methacrylic anhydride (MA) to synthesize GelMA, which showed the admirable UV light activatable polymerizing ability. Aldehyde groups, which cross-linked with the -NH2 on the tissue surface and afforded the tissue adhesion, were produced by oxidizing the o-hydroxyl groups of dextran. Further, the sodium tetraborate formed dynamic boric acid ester bonds with the oxidized dextran (OD). With this triple-network structure, the as-prepared hydrogel presented excellent hemostatic capacity and surmounted a high blood pressure of 165 mmHg, which is higher than the threshold systolic blood pressure of healthy adults (i.e., 120 mmHg). The mechanical property, morphology, biocompatibility and degradation of the hydrogel were character Borax, the hydrogel successfully blocked the bleeding and accelerated the wound healing. This research provides a new modality for the design of a multifunctional hemostatic hydrogel for effective hemostasis and wound healing.
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