4.3 Review

Machine learning to empower electrohydrodynamic processing

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ELSEVIER
DOI: 10.1016/j.msec.2021.112553

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3D printing drug products; Continuous manufacturing; Nanotechnology; Digital healthcare technology; Informatics; Functional materials; 2D materials

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Electrohydrodynamic (EHD) processes show promise in healthcare fabrication, and the incorporation of machine learning (ML) is expected to enhance EHD workflows and improve production efficiency.
Electrohydrodynamic (EHD) processes are promising healthcare fabrication technologies, as evidenced by the number of commercialised and food-and-drug administration (FDA)-approved products produced by these processes. Their ability to produce both rapidly and precisely nano-sized products provides them with a unique set of qualities that cannot be matched by other fabrication technologies. Consequently, this has stimulated the development of EHD processing to tackle other healthcare challenges. However, as with most technologies, time and resources will be needed to realise fully the potential EHD processes can offer. To address this bottleneck, researchers are adopting machine learning (ML), a subset of artificial intelligence, into their workflow. ML has already made ground-breaking advancements in the healthcare sector, and it is anticipated to do the same in the materials domain. Presently, the application of ML in fabrication technologies lags behind other sectors. To that end, this review showcases the progress made by ML for EHD workflows, demonstrating how the latter can benefit greatly from the former. In addition, we provide an introduction to the ML pipeline, to help encourage the use of ML for other EHD researchers. As discussed, the merger of ML with EHD has the potential to expedite novel discoveries and to automate the EHD workflow.

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