A highly efficient nanostructured Au@La2O3 based platform for dopamine detection

In the present work, nanostructured La2O3 and Au doped La2O3 nanocomposites were prepared hydrothermally that were further deposited electrophoretically onto the indium-tin-oxide (ITO) glass surface. The tymsinase enzyme (Tyr) have been immobilized on the AuNPs modified La2O3/ITO electrode. The fabricated electrode Tyr/Au-La2O3/ITO was utilized for the determination of dopamine. The structural and morphological characterization were done by X-ray diffraction (XRD), Fourier transform infrared (FTIR), Atomic force microscopy (AFM), Transmission electron microscopy (TEM & HR-TEM) and Energy dispersive X-ray analysis (EDX). The results of electrochemical response studies of fabricated electrode Tyr/Au-La2O3/ITO exhibit a linear range of 2-100 mu m, sensitivity 2.4806 x 10(-7) A/mu M and limit of detection of 0.258 mu M with response time 30 s and good reproducibility. The fabricated electrode might provide an efficient biointerface for the application of the rare earth metal oxide nanomaterials in biosensors and bioelectronics.

Automated summary

In this study, nanostructured La2O3 and Au doped La2O3 nanocomposites were prepared hydrothermally and electrophoretically deposited onto ITO glass for the immobilization of tymsinase enzyme. The fabricated Tyr/Au-La2O3/ITO electrode showed promising results for dopamine determination with good sensitivity and reproducibility. Overall, the fabricated electrode could provide an efficient biointerface for the application of rare earth metal oxide nanomaterials in biosensors and bioelectronics.