Duplex modification of hydroxyapatite using co-substitution and dual deposition

Hydroxyapatite (HA) is a famous bioceramic. Nevertheless, weak antibacterial ability prevents the further application of HA. In the present work, hydroxyapatite nanoparticle (nano-HA) was duplex modified using cosubstitution and dual deposition to improve its antibacterial ability. Nano-HA with a pure HA structure and co-substituted with copper and zinc ions was obtained by a modified precipitation method. Zinc oxide and copper nanoparticles were successfully deposited on the surface of the co-substituted nano-HA using a two-step liquid chemical reduction method. The result of element analysis demonstrates that the co-substitution treatment improves the subsequent dual deposition effect. The result of the antibacterial test indicates that the duplex modification significantly promotes the antibacterial ability of HA.

Automated summary

This study successfully enhanced the antibacterial ability of hydroxyapatite nanoparticles through cosubstitution and dual deposition methods, demonstrating a significant improvement in the antibacterial performance of HA.