期刊
MATERIALS CHEMISTRY AND PHYSICS
卷 271, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.matchemphys.2021.124879
关键词
Hydroxyapatite; Polycaprolactone; Nanofiber; Wound healing; Thallium; Vanadium
资金
- Taif University, Taif, Saudi Arabia [TURSP2020/200]
The electrospun nanofibrous scaffolds containing codoped HAP in PCL demonstrated good microstructure, mechanical properties, and antibacterial efficacy. By altering the Tl ion ratio, the surface morphology and antibacterial effects of the nanofiber scaffolds can be effectively controlled.
Polymer-based electrospun nanofibrous scaffolds containing polycaprolactone (PCL) were encapsulated with codoped hydroxyapatite (HAP). The modification of HAP includes co-doped thallium (Tl+)/vanadate (VO43-) at different contributions of Tl+ ions. The obtained powdered and nanofibrous phases have been investigated upon their structure, morphology, and microstructure. The investigation of the surface morphology indicated that the scaffolds were formed in networked nanofibers with diameters around 0.2-0.8 mu m to 43-80 nm for the lowest and the highest Tl ions contents through nanofibers. Besides, the maximum height of the roughness (R-t) increased from 190.2 to 242.7 nm for the powdered compositions, while it started from 395.9 nm and increased to 861.0 nm for the nanofibers scaffolds. Furthermore, the mechanical properties were tested and showed that the toughness increased from 0.56 +/- 0.11 to 2.52 +/- 0.83 MJ/m(3). The contact angle was measured and exhibited a decreasing behavior starting from 101.2 +/- 2.5 to 87.6 +/- 4.3 degrees. In addition, the antibacterial potency was examined, and the inhibition zone increased up to 21.4 +/- 1.1 and 20.4 +/- 1.2 mm against E. coli and S. aureus, respectively. The in vitro culturing of human fibroblasts cell line through the scaffolds showed that the cells were spread and grew robustly upon the compositional variation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据