Properties of a nanobioglass synthesized from rice husk for bone prostheses applications

The increase in life expectancy of the population has resulted in increased bone inflammatory degenerative problems. In this context, the present work aims the development and characterization of nanobioglass (NPs-BV) using (agro)industrial residues from rice husk, to improve the osteoconductivity for bone tissue applications. For the syntheses of nanobioglass was used the sol-gel process, using silica extracted from rice husk ash and magnesium nanoxide with nanobioglass (MgNPs-BV). Experimental planning was carried out using Central Composite Rotational Design (CCRD 22) in the order to get the ideal conditions (pH and time) for the synthesis of nanobioglass. About the CCRD 22, ideal condition was pH = 8.0 and t = 20 min with an average diameter of 1.51 nm. About the NPs-BV and MgNPs-BV presented amorphous characteristics and average crystallite size of 1.35-2.11 nm, respectively. Regarding the biological tests, the NPs-BV and MgNPs-BV extracts showed a high safety profile of cytotoxicity, biocompatibility, and bioactivity, highlighting the 100% MgNPs-BV extract, as it presented twice the cell proliferation when compared to the negative control. Therefore, nanobioglass containing magnesium can be used with a scaffold in processes involving bone regeneration and can be considered a promising biomaterial to be developed.

Automated summary

The study focuses on developing and characterizing nanobioglass from rice husk residues to enhance osteoconductivity for bone tissue applications. The experimental results show that nanobioglass containing magnesium exhibits excellent cellular safety, biocompatibility, and bioactivity, making it a promising biomaterial for bone regeneration.