期刊
MARINE DRUGS
卷 19, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/md19120699
关键词
obesity; brown seaweed; polysaccharide; nonalcoholic fatty liver disease; gut microbiota
资金
- Scientific Research Foundation of Third Institute of Oceanography, Ministry of Natural Resources [2017007, 2017032, 2017026]
- Fujian Provincial Science and Technology Project [2018N0014]
- Marine Economy Innovation Development Area Demonstration Project of Beihai [Bhsfs009, Bhsfs010]
The polysaccharide derived from Laminaria japonica can reduce obesity-related abnormalities, modulate gene expressions related to lipid and cholesterol metabolism in the liver, and improve hepatic steatosis caused by a high-fat diet; additionally, it can also improve obesity-related dysbiosis by regulating gut microbiota.
In this study, the effects of a polysaccharide derived from Laminaria japonica (LJP) on obesity were investigated in mice fed a high-fat diet (HFD). LJP significantly attenuated obesity-related features, lowering serum triglycerides, glucose, total cholesterol and low-density lipoprotein cholesterol levels. HFD-induced liver steatosis and hepatocellular ballooning were significantly attenuated by LJP. Additionally, LJP was found to significantly modulate hepatic gene expressions of AMPK and HMGCR, which are key regulators of lipid and cholesterol metabolism. We further found that LJP ameliorated HFD-induced gut microbiota (GM) dysbiosis by significantly reducing the obesity-related Firmicutes to Bacteroidetes ratio, meanwhile promoting the growth of Verrucomicrobia at the phylum level. At the genus level, propionate-producing bacteria Bacteroides and Akkermansia were elevated by LJP, which might explain the result that LJP elevated fecal propionate concentration. Taken together, these findings suggest that dietary intake of LJP modulates hepatic energy homeostasis to alleviate obesity-related nonalcoholic fatty liver disease associated with GM regulation.
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