4.7 Review

Recent Updates on Marine Cancer-Preventive Compounds

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Article Oncology

Alteration of fecal microbiota by fucoxanthin results in prevention of colorectal cancer in AOM/DSS mice

Masaru Terasaki et al.

Summary: Fucoxanthin has been shown to have anticancer properties in a mouse model of inflammation-associated colorectal cancer, with alterations in the gut microbiota playing a potentially key role in its chemopreventive effect.

CARCINOGENESIS (2021)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Cell Biology

Squalene deters drivers of RCC disease progression beyond VHL status

Karthikeyan Rajamani et al.

Summary: Squalene derived from marine brown algae demonstrates strong anti-cancer activity against RCC by targeting the HIF-signaling pathway and affecting various cellular processes. Its efficacy beyond VHL status highlights its potential as a promising drug candidate for RCC.

CELL BIOLOGY AND TOXICOLOGY (2021)

Article Environmental Sciences

Chemopreventive effect of dieckol against 7,12-dimethylbenz(a)anthracene induced skin carcinogenesis model by modulatory influence on biochemical and antioxidant biomarkers

Wenming Xiao et al.

Summary: Dieckol supplementation significantly restored body and tumor weights, enhanced antioxidant capacity, suppressed inflammation, reduced enzyme activity, promoted apoptosis, and demonstrated therapeutic effects against skin cancer.

ENVIRONMENTAL TOXICOLOGY (2021)

Article Food Science & Technology

Octopus vulgaris ink extracts exhibit antioxidant, antimutagenic, cytoprotective, antiproliferative, and proapoptotic effects in selected human cancer cell lines

Martin Samuel Hernandez-Zazueta et al.

Summary: O. vulgaris ink, particularly the dichloromethane extract, demonstrates potential health benefits such as antimutagenic, cytoprotective, and antiproliferative effects on human cancer cell lines. The discovery of a novel compound in the purified fractions highlights the promising bioactivity of understudied marine natural products like OI, which may have implications for cancer prevention and treatment. Further research is needed to explore the mechanisms and health benefits of OI at different levels of investigation.

JOURNAL OF FOOD SCIENCE (2021)

Review Chemistry, Medicinal

Marine Pharmacology in 2016-2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Alejandro M. S. Mayer et al.

Summary: The review of marine pharmacology literature in 2016-2017 evaluated 313 marine compounds with novel pharmacology, reported by researchers from 54 countries. The peer-reviewed literature documented various activities of 123 marine natural products, including antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities, as well as 111 marine compounds with anti-diabetic and anti-inflammatory activities. These findings contribute to the global research for novel therapeutic strategies across multiple disease categories.

MARINE DRUGS (2021)

Review Biochemistry & Molecular Biology

Microbial production of medium-chain length polyhydroxyalkanoates

Juliana B. Silva et al.

Summary: Medium-chain-length poly(hydroxyalkanoates), or mcl-PHAs, are naturally produced polymers known for their low crystallinity and material properties suitable for diverse applications. Despite their valuable properties, mcl-PHAs face limitations in commercial development due to high production and extraction costs.

PROCESS BIOCHEMISTRY (2021)

Article Chemistry, Medicinal

Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors

Virginia Spano et al.

Summary: A series of [1,3]thiazolo[4,5-e]isoindoles have been synthesized with high antiproliferative activity, with compound 11g showing the highest potency to induce cell cycle arrest and apoptosis. This compound could serve as a lead compound for new antimitotic drug discovery.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Oncology

Cancer statistics for the year 2020: An overview

Jacques Ferlay et al.

Summary: The study briefly reviews the methods and data sources used in compiling the IARC GLOBOCAN cancer statistics for 2020 and summarizes the main results. It estimated that there were nearly 19.3 million new cancer cases and almost 10 million cancer deaths worldwide in 2020, with the most commonly diagnosed cancers being female breast cancer and lung cancer, and the most common causes of cancer death being lung cancer and liver cancer.

INTERNATIONAL JOURNAL OF CANCER (2021)

Article Chemistry, Medicinal

The Inhibition Effect of the Seaweed Polyphenol, 7-Phloro-Eckol from Ecklonia Cava on Alcohol-Induced Oxidative Stress in HepG2/CYP2E1 Cells

Liyuan Lin et al.

Summary: The study demonstrated that 7-phloro-eckol (7PE) can significantly alleviate alcohol-induced oxidative stress injury and may have potential application prospects as an antioxidant.

MARINE DRUGS (2021)

Article Chemistry, Medicinal

Svalbamides A and B, Pyrrolidinone-Bearing Lipodipeptides from Arctic Paenibacillus sp.

Young Eun Du et al.

Summary: Two new secondary metabolites, svalbamides A and B, isolated from a culture extract of Paenibacillus sp. SVB7, showed potential as chemopreventive agents by inducing quinone reductase activity in Hepa1c1c7 murine hepatoma cells.

MARINE DRUGS (2021)

Article Oncology

Effect of Fucoxanthinol on Pancreatic Ductal Adenocarcinoma Cells from an N-Nitrosobis(2-oxopropyl)amine-initiated Syrian Golden Hamster Pancreatic Carcinogenesis Model

Masaru Terasaki et al.

Summary: This study showed that FxOH has a significant inhibitory effect on certain pancreatic cancer cells by regulating cell cycle and multiple signaling pathways.

CANCER GENOMICS & PROTEOMICS (2021)

Review Biochemistry & Molecular Biology

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

Lei Zhong et al.

Summary: Targeted therapeutic drugs have become mainstream cancer treatments due to their advantages in efficacy and safety, but still face challenges such as low response rate and drug resistance. A comprehensive review was conducted on small-molecule targeted anti-cancer drugs to promote their development, discussing current challenges and providing insights and perspectives for future research and development.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Biochemistry & Molecular Biology

Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents

He-Ming Zhou et al.

Summary: Understanding the key characteristics and resistance mechanisms of CSCs may improve patient outcomes and reduce relapse. Targeting the mechanisms and pathways of CSCs described in this review could lead to further drug discovery and therapy development.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Pharmacology & Pharmacy

Mediterranean diet and health status: Active ingredients and pharmacological mechanisms

Lukas Schwingshackl et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression

Michelle S. Bousquet et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Editorial Material Chemistry, Medicinal

Marine Compounds and Cancer: The First Two Decades of XXI Century

Sergey A. Dyshlovoy et al.

MARINE DRUGS (2020)

Review Chemistry, Medicinal

Bioactive pyrrole-based compounds with target selectivity

Giovanna Li Petri et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Editorial Material Chemistry, Medicinal

Marine Compounds and Cancer: Updates 2020

Sergey A. Dyshlovoy et al.

MARINE DRUGS (2020)

Review Chemistry, Medicinal

Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes

Marilia Barreca et al.

MARINE DRUGS (2020)

Article Biochemistry & Molecular Biology

Fucoxanthin potentiates anoikis in colon mucosa and prevents carcinogenesis in AOM/DSS model mice

Masaru Terasaki et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2019)

Review Genetics & Heredity

Resolving genetic heterogeneity in cancer

Samra Turajlic et al.

NATURE REVIEWS GENETICS (2019)

Review Oncology

Tumour heterogeneity and resistance to cancer therapies

Ibiayi Dagogo-Jack et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Review Chemistry, Applied

The promise of marine molecules as cosmetic active ingredients

E. G. Brunt et al.

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE (2018)

Review Food Science & Technology

Current Insights into the Biological Action of Squalene

Jose M. Lou-Bonafonte et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2018)

Article Nutrition & Dietetics

A marine bio-functional lipid, fucoxanthinol, attenuates human colorectal cancer stem-like cell tumorigenicity and sphere formation

Masaru Terasaki et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2017)

Review Oncology

Anticancer and cancer preventive compounds from edible marine organisms

Marta Correia-da-Silva et al.

SEMINARS IN CANCER BIOLOGY (2017)

Review Plant Sciences

Chaetomium endophytes: a repository of pharmacologically active metabolites

Nighat Fatima et al.

ACTA PHYSIOLOGIAE PLANTARUM (2016)

Article Food Science & Technology

Cytotoxic activity of aeroplysinin-1 against colon cancer cells by promoting β-catenin degradation

Seoyoung Park et al.

FOOD AND CHEMICAL TOXICOLOGY (2016)

Editorial Material Chemistry, Medicinal

Marine Compounds and Cancer: Where Do We Stand?

Sergey A. Dyshlovoy et al.

MARINE DRUGS (2015)

Review Chemistry, Medicinal

Marine-Based Nutraceuticals: An Innovative Trend in the Food and Supplement Industries

Hafiz Ansar Rasul Suleria et al.

MARINE DRUGS (2015)

Article Food Science & Technology

Antimutagenic, antiproliferative, and antioxidant effect of extracts obtained from octopus (Paraoctopus limaculatus)

Susana-Gabriela Cruz-Ramirez et al.

FOOD SCIENCE AND TECHNOLOGY (2015)

Review Agronomy

Marine microalgae used as food supplements and their implication in preventing cardiovascular diseases

Virginie Mimouni et al.

OCL-OILSEEDS AND FATS CROPS AND LIPIDS (2015)

Review Chemistry, Medicinal

Marine Low Molecular Weight Natural Products as Potential Cancer Preventive Compounds

Valentin A. Stonik et al.

MARINE DRUGS (2014)

Article Environmental Sciences

Protective effect of a marine polyphenol, dieckol against carbon tetrachloride-induced acute liver damage in mouse

Min-Cheol Kang et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2013)

Review Oncology

Tumor promoters: from chemicals to inflammatory proteins

Hirota Fujiki et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2013)

Review Medicine, General & Internal

Fish Consumption and Colorectal Cancer Risk in Humans: A Systematic Review and Meta-analysis

Shengjun Wu et al.

AMERICAN JOURNAL OF MEDICINE (2012)

Review Biochemistry & Molecular Biology

Regulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant Genes

Young-Sam Keum

BIOMOLECULES & THERAPEUTICS (2012)

Article Nutrition & Dietetics

Pharmacokinetics of fucoxanthinol in human plasma after the oral administration of kombu extract

Takashi Hashimoto et al.

BRITISH JOURNAL OF NUTRITION (2012)

Article Biodiversity Conservation

Historical, cultural and social perspectives on luxury seafood consumption in China

Michael Fabinyi

ENVIRONMENTAL CONSERVATION (2012)

Editorial Material Medicine, General & Internal

Tumor Heterogeneity and Personalized Medicine

Dan L. Longo

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Biochemistry & Molecular Biology

New class azaphilone produced by a marine fish-derived Chaetomium globosum. The stereochemistry and biological activities

Takeshi Yamada et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2011)

Review Biochemistry & Molecular Biology

Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds

Yanyan Li et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2011)

Review Food Science & Technology

Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds

Min-Hsiung Pan et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2011)

Review Immunology

HMGB1 and RAGE in Inflammation and Cancer

Gary P. Sims et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 28 (2010)

Article Agriculture, Multidisciplinary

Chemical composition and nutritional quality of sea cucumbers

Jing Wen et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2010)

Article Biochemistry & Molecular Biology

Chemical components and its antioxidant properties in vitro: An edible marine brown alga, Ecklonia cava

Yong Li et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Review Biotechnology & Applied Microbiology

Molecular targets for cancer chemoprevention

William N. William et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Article Biotechnology & Applied Microbiology

Chaetomugilins, New Selectively Cytotoxic Metabolites, Produced by a Marine Fish-derived Chaetomium Species

Muroga Yasuhide et al.

JOURNAL OF ANTIBIOTICS (2008)

Article Biochemistry & Molecular Biology

Cytotoxic and antiplasmodial substances from marine-derived fungi, Nodulisporium sp and CRI247-01

Chairut Kasettrathat et al.

PHYTOCHEMISTRY (2008)

Article Oncology

Photochemoprevention of UVB-induced skin carcinogenesis in SKH-1 mice by brown algae polyphenols

Hyejeong Hwang et al.

INTERNATIONAL JOURNAL OF CANCER (2006)

Review Oncology

Nature and nurture - Lessons from chemical carcinogenesis

A Luch

NATURE REVIEWS CANCER (2005)

Review Biochemistry & Molecular Biology

The role of genetic polymorphisms in metabolism of carcinogenic heterocyclic aromatic amines

RJ Turesky

CURRENT DRUG METABOLISM (2004)

Review Oncology

Cancer chemoprevention with dietary phytochemicals

YJ Surh

NATURE REVIEWS CANCER (2003)

Review Genetics & Heredity

The fundamental role of epigenetic events in cancer

PA Jones et al.

NATURE REVIEWS GENETICS (2002)

Article Cell Biology

The role of AP-1, NF-κB and ROS/NOS in skin carcinogenesis:: The JB6 model is predictive

A Dhar et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2002)

Review Oncology

Helicobacter pylori and gastrointestinal tract adenocarcinomas

RM Peek et al.

NATURE REVIEWS CANCER (2002)

Article Multidisciplinary Sciences

Proteinase inhibitors I and II from potatoes block UVB-induced AP-1 activity by regulating the AP-1 protein compositional patterns in JB6 cells

GM Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Review Oncology

Metabolism of chemical carcinogens

FP Guengerich

CARCINOGENESIS (2000)