期刊
MAGNETIC RESONANCE IN MEDICINE
卷 87, 期 5, 页码 2536-2550出版社
WILEY
DOI: 10.1002/mrm.29148
关键词
arterial input function; breast cancer; capillary input function; deep learning; dynamic contrast enhanced MRI
资金
- NIH [R01CA160620, R01CA219964, UG3CA228699, R01EB024532, R21EB027241, P41EB017183]
- National Institutes of Health
This study develops a deep learning approach to estimate the local capillary-level input function (CIF) for pharmacokinetic model analysis of DCE-MRI. The results show that the proposed approach using CIF estimation can detect malignancy in clinical settings without the need for manual measurement of arterial input function (AIF).
Purpose To develop a deep learning approach to estimate the local capillary-level input function (CIF) for pharmacokinetic model analysis of DCE-MRI. Methods A deep convolutional network was trained with numerically simulated data to estimate the CIF. The trained network was tested using simulated lesion data and used to estimate voxel-wise CIF for pharmacokinetic model analysis of breast DCE-MRI data using an abbreviated protocol from women with malignant (n = 25) and benign (n = 28) lesions. The estimated parameters were used to build a logistic regression model to detect the malignancy. Result The pharmacokinetic parameters estimated using the network-predicted CIF from our breast DCE data showed significant differences between the malignant and benign groups for all parameters. Testing the diagnostic performance with the estimated parameters, the conventional approach with arterial input function (AIF) showed an area under the curve (AUC) between 0.76 and 0.87, and the proposed approach with CIF demonstrated similar performance with an AUC between 0.79 and 0.81. Conclusion This study shows the feasibility of estimating voxel-wise CIF using a deep neural network. The proposed approach could eliminate the need to measure AIF manually without compromising the diagnostic performance to detect the malignancy in the clinical setting.
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