期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 42, 期 23, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.202100556
关键词
N-cyanomethylacrylamide; RAFT polymerization; thermoresponsiveness; UCST-type (co)polymers
A new family of UCST-thermoresponsive polymers based on N-cyanomethylacrylamide (CMAm) were synthesized and demonstrated to have well-controlled phase transitions and molar mass dependent transition temperatures. By copolymerizing with acrylamide or acrylic acid, the transition temperature can be modulated over a wide range, resulting in thermoresponsive and pH responsive copolymers that show sharp and reversible UCST-type transitions close to physiological temperature, making them promising candidates for biomedical applications.
In this present work, the synthesis of a new family of upper critical solution temperature (UCST)-thermoresponsive polymers based on N-cyanomethylacrylamide (CMAm) is reported. It is demonstrated that the thermally initiated reversible addition fragmentation chain transfer (RAFT) polymerization of CMAm conducted in N,N-dimethylformamide (DMF) is well controlled. The homopolymer presents a sharp and reversible UCST-type phase transition in pure water with a very small hysteresis between cooling and heating cycles. It is demonstrated that the cloud point (T-CP) of poly(N-cyanomethylacrylamide) (PCMAm) is strongly molar mass dependent and shifts toward lower temperatures in saline water. Moreover, the transition temperature can be tuned over a large temperature range by copolymerization of CMAm with acrylamide or acrylic acid. The latter copolymers are both thermoresponsive and pH responsive. Interestingly, by this strategy sharp and reversible UCST-type transitions close to physiological temperature can be reached, which makes the copolymers extremely interesting candidates for biomedical applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据