期刊
MACROMOLECULAR BIOSCIENCE
卷 22, 期 3, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.202100432
关键词
drug delivery; hydrogel; in situ gels; mucoadhesion; stimuli-responsive polymers
资金
- EPSRC [EP/T00813X/1]
- Royal Society [RG160139]
- University of Hertfordshire
- Ministry of Education and Science of the Republic of Kazakhstan [AP08052780]
- EPSRC [EP/T00813X/1] Funding Source: UKRI
Thermoreversible gels transitioning between liquid-like and solid-like states have enabled breakthroughs in novel healthcare technologies. This study synthesized ABA copolymers with varying molecular weights of PDEA and PEG blocks, revealing the necessity of high molecular weight PEG blocks for forming solid-like thermoreversible gels. Optimization led to a mucoadhesive, stable, and non-toxic thermoreversible gel with controlled release of hydrophobic drugs, showcasing high promise for healthcare applications.
Thermoreversible gels which transition between liquid-like and solid-like states when warmed have enabled significant novel healthcare technologies. Poly(N,N-diethyl acrylamide) (PDEA) is a thermoresponsive polymer which can be used as a trigger to form thermoreversible gels, however its use in these materials is limited and crucial design principles are unknown. Herein ABA copolymers with the structure PDEA-b-poly(ethylene glycol) (PEG)-b-PDEA are synthesized to give four block copolymers with varied molecular weight of PDEA and PEG blocks. Rheometry on solutions of the block copolymers reveals that high molecular weight PEG blocks are required to form thermoreversible gels with predominantly solid-like behavior. Furthermore, small-angle X-ray scattering elucidates clear differences in the nanostructure of the copolymer library which can be linked to distinct rheological behaviors. A thermoreversible gel formulation based on PDEA (20 kDa)-b-PEG (10 kDa)-b-PDEA (20 kDa) is designed by optimizing the polymer concentration and ionic strength. It is found that the gel is mucoadhesive, stable, and non-toxic, as well as giving controlled release of a hydrophobic drug. Overall, this study provides insight into the effect of polymer architecture on the nanostructure and rheology of PDEA-b-PEG-b-PDEA and presents the development of a highly functional thermoreversible gel with high promise for healthcare applications.
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