☆ 4.0 Editorial Material

A novel role for thrombospondins in abnormal neuroplasticity associated with behavioral disorders in adult mice

M S-MEDECINE SCIENCES (2022)

Cocaine Triggers Astrocyte-Mediated Synaptogenesis

Junshi Wang et al.

Summary: The study shows that the developmental synaptogenic mechanism mediated by astrocyte-released thrombospondins (TSPs) and their neuronal receptor alpha 2 delta-1 is utilized during cocaine experience to induce spinogenesis and the generation of AMPA receptor-silent glutamatergic synapses in the adult nucleus accumbens shell (NAcSh). Further research indicates that disruption of TSP2-alpha 2 delta-1-mediated spinogenesis and synapse generation in NAcSh reduces cue-induced cocaine seeking after withdrawal from cocaine self-administration and cue-induced reinstatement of cocaine seeking after drug extinction.

BIOLOGICAL PSYCHIATRY (2021)

添加到收藏夹

Review Medicine, Research & Experimental

New technologies to unveil the role of brain glial cells

Anne-Laure Hemonnot-Girard et al.

Summary: Complex interactions between neurons and various types of glial cells play a crucial role in brain function. The thriving field of gliobiology, fueled by technical innovations, is unraveling the multiple roles of glial cells in brain function and dysfunction. Cutting-edge experimental approaches are being used to understand the importance of glial cells in the central nervous system and translate findings into new biomarkers and therapeutic strategies.

M S-MEDECINE SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology