期刊
LWT-FOOD SCIENCE AND TECHNOLOGY
卷 150, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.lwt.2021.112057
关键词
Liposomes; Cross-linked chitosan; Fish peptide; Nanovesicle elucidations; Antioxidant efficiency
资金
- Iran National Science Foundation (INSF) [98028846]
- Tarbiat Modares University [IG-39804]
The study aimed to develop novel hybrid nanocarriers for fish-purified antioxidant peptide, utilizing liposomes coated with chitosan cross-linked with sodium tripolyphosphate. The produced nanodispersion demonstrated good stability and retained antioxidant activity, presenting a promising approach for delivering protein hydrolysates and peptide fractions in nutraceutical and functional foods.
The aim of this work was to develop novel hybrid nanocarriers made of liposomes coated with chitosan (CS) cross-linked with sodium tripolyphosphate (TPP), named CS-TPP/liposomes, for fish-purified antioxidant peptide fractionated by RP-HPLC (F5). The produced nanodispersion (peptide-loaded CS-TPP/liposomes) was characterized by dynamic light scattering (DLS), high-resolution transmission electron microscopy (HRTEM), Fourier transform infrared (FT-IR) spectroscopy, and differential scanning calorimetry (DSC). The mean nanoparticle sizes of these uncoated and CS-TPP coated liposomes were found to be 409.2 and 687.4 nm, respectively, and the obtained polydispersity index (PDI) was <= 0.2. HRTEM revealed the spherical shape and smooth surface of the produced peptide-loaded nanovesicles. FT-IR spectroscopy revealed that the liposomes have been successfully coated by CS-TPP. In addition, DSC findings indicated enhanced electrostatic interactions among CS and lecithin molecules, leading to an increase in the melting (T-m) and decomposition temperature (T-d) in peptide-loaded CSTPP/liposomes hybrid system. Furthermore, the antioxidant activity of the loaded fish-purified antioxidant peptide to CS-TPP/liposomes was retained as confirmed by the employed free radical scavenging assay. The proposed hybrid system represents a promising idea for the delivery of protein hydrolysate and peptide fractions thereof in nutraceutical and functional foods applications.
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