☆ 4.5 Article

Identification of a EML4-ALK exon 19 fusion variant in lung adenocarcinoma and alectinib resistance

LUNG CANCER (2021)

Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

Asmin Tulpule et al.

Summary: A membraneless, protein granule-based subcellular structure has been identified to organize RTK/RAS/MAPK signaling in cancer cells, actively signaling within the cytoplasm and activating RAS independently of lipid membranes. The formation of RTK protein granules is critical for oncogenic RAS/MAPK signaling output in these cells. This study reveals a distinct subcellular platform for organizing oncogenic RTK and RAS signaling through higher-order cytoplasmic protein assembly.

CELL (2021)

添加到收藏夹

Article Oncology

Going beneath the tip of the iceberg. Identifying and understanding EML4-ALK variants and TP53 mutations to optimize treatment of ALK fusion positive (ALK plus ) NSCLC

Shannon S. Zhang et al.

Summary: This study discusses the impact of EML4-ALK variants on NSCLC and response to ALK TKIs. EML4-ALK 1 and 3 are the most common variants, dominant in ALK+ NSCLC. Short (v3 and v5) and long (v1, v2, v5', v7, and v8) EML4-ALK variants show differential response to TKIs.

LUNG CANCER (2021)

添加到收藏夹

Article Oncology