期刊
LUMINESCENCE
卷 37, 期 5, 页码 713-721出版社
WILEY
DOI: 10.1002/bio.4212
关键词
aqueous humour; cromolyn sodium; inner filter effect; nitrogen; sulfur-carbon quantum dots
资金
- Mansoura University [Mu-phra-21-12]
A simple and eco-friendly hydrothermal technique was used to prepare water soluble N- and S-co-doped carbon quantum dots probes. The synthesized N,S-CQDs showed high luminescence and were used as an optical nanosensor for detecting cromolyn sodium in pharmaceutical dosage forms. The method was optimized and validated according to the International Council of Harmonisation guidelines and proved to be environmentally friendly.
A simple and eco-friendly hydrothermal technique is used to prepare water soluble N- and S-co-doped carbon quantum dots probes (N,S-CQDs) from thiosemicarbazide and citric acid. Several characterization techniques were performed to ensure the successful synthesis of highly luminescent N,S-CQDs. The prepared probe exhibited analytical potential as an optical nanosensor for the spectrofluorimetric determination of cromolyn sodium (CRO) in its pharmaceutical dosage forms and aqueous humour. The emission intensity of the synthesized N,S-CQDs was measured at 411 nm after excitation at 345 nm. Addition of increasing concentrations of CRO to N,S-CQDs led to quenching of its fluorescence intensity. CRO was investigated within a wide concentration range 10.0-150.0 mu M with a limit of detection of 2.0 mu M and a limit of quantification of 6.0 mu M. The quenching of fluorescent N,S-CQDs occurred through the inner filter effect (IFE). The developed spectrofluorimetric method was successfully optimized and validated according to the International Council of Harmonisation guidelines (ICH). The method greenness is proved through using both Eco-Scale and AGREE approaches.
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