期刊
LIPIDS IN HEALTH AND DISEASE
卷 20, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12944-021-01553-2
关键词
In-stent restenosis; Coronary heart disease; Percutaneous coronary intervention; Risk factors
资金
- foundation of State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia [SKL-HIDCA-2020-47]
- Training Program of National Science Foundation for Distinguished Young Scholar [xyd2021J004]
- National Natural Science Foundation of China [81860072, U1903304]
- third Training Program of Tianshan Talents of Xinjiang Department of Human Resources and Social Security [37 [2021]]
In the Xinjiang population of China, the incidence of ISR in CAD patients with DES implantation is 5.79%. The prediction model based on PDW, SBP, TC, LDL-C, and lesion vessels is an effective tool for predicting ISR.
Background The present study was aimed to establish a prediction model for in-stent restenosis (ISR) in subjects who had undergone percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Materials and methods A retrospective cohort study was conducted. From September 2010 to September 2013, we included 968 subjects who had received coronary follow-up angiography after primary PCI. The logistic regression analysis, receiver operator characteristic (ROC) analysis, nomogram analysis, Hosmer-Lemeshow chi(2) statistic, and calibration curve were applied to build and evaluate the prediction model. Results Fifty-six patients (5.79%) occurred ISR. The platelet distribution width (PDW), total cholesterol (TC), systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), and lesion vessels had significant differences between ISR and non-ISR groups (all P < 0.05). And these variables were independently associated with ISR (all P < 0.05). Furthermore, they were identified as predictors (all AUC > 0.5 and P < 0.05) to establish a prediction model. The prediction model showed a good value of area under curve (AUC) (95%CI): 0.72 (0.64-0.80), and its optimized cut-off was 6.39 with 71% sensitivity and 65% specificity to predict ISR. Conclusion The incidence of ISR is 5.79% in CAD patients with DES implantation in the Xinjiang population, China. The prediction model based on PDW, SBP, TC, LDL-C, and lesion vessels was an effective model to predict ISR in CAD patients with DESs implantation.
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