期刊
LEUKEMIA & LYMPHOMA
卷 62, 期 14, 页码 3474-3483出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2021.1961238
关键词
Mantle cell lymphoma; allogeneic stem cell transplantation; ibrutinib
The role of allogeneic stem cell transplantation in mantle cell lymphoma remains uncertain, but this study suggests that it can be a viable option for some patients, especially young and early-relapsed individuals.
The role of allogeneic stem cell transplantation (allo-SCT) in mantle cell lymphoma (MCL) is uncertain, even more in the era of bruton's tyrosine kinase inhibitors (BTKi) and chimeric antigen receptor T-cells. We retrospectively analyzed 55 patients who underwent allo-SCT for MCL relapsed or refractory (r/r) after rituximab and high-dose cytarabine within the MANTLE-FIRST project. With a median follow-up of 3.7 years, non-relapse mortality (NRM), progression-free survival, and overall survival were 23%, 53%, and 56%, respectively. NRM was significantly higher in the case of acute graft-versus-host disease, > 2 prior lines of therapy, age > 60 years. The outcome was similar for patients with early (<= 24 months) and late progression of disease. The use of BTKi as a bridge to allo-SCT did not increase the toxicity and allowed a good control of disease. Our real-life experience confirms that allo-SCT still represents an option in MCL patients, especially if young and early-relapsed.
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