4.2 Article

An Ultrasound-Assisted Solvent and Catalyst-Free Synthesis of Structurally Diverse Pyrazole Centered 1,5-disubstituted Tetrazoles via One-Pot Four-Component Reaction

期刊

LETTERS IN ORGANIC CHEMISTRY
卷 19, 期 9, 页码 795-802

出版社

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570178619666211220094516

关键词

Ultrasound irradiation; 1; 5-disubstituted tetrazole; pyrazole; catalyst-free; solvent-free; multi-component reaction; green protocol

资金

  1. Council of Scientific and Industrial Research, India [09/1264(0001)/19-EMR-I, 321158/2K18/1]
  2. SERB-DST New Delhi, India [EMR/2016/002123]

向作者/读者索取更多资源

In this article, the authors reported the synthesis of a series of medicinally relevant 1,5-disubstituted tetrazoles using ultrasound irradiation via a one-pot 4-C reaction. The synthesized compounds were characterized by various spectroscopic techniques. The ultrasound-assisted green protocol exhibited advantages such as mild reaction conditions, high yield, catalyst and solvent-free reaction, short reaction time, and easy workup.
1,5-Disubstituted tetrazoles are vital drug-like scaffolds usually encountered as valuable bioisosteres of the cis-amide bond. In this article, we reported the synthesis of some novel medicinally relevant pyrazole centered 1,5-disubstituted tetrazoles using ultrasound irradiation via a one-pot 4-C reaction from various pyrazole originated aldehyde, amine, isocyanide, and sodium azide. All the synthesized derivatives were characterized by IR, H-1 NMR, C-13 NMR, spectroscopic techniques, and mass analysis. This ultrasound-assisted green protocol has several advantages like mild reaction condition, high yield, catalyst and solvent-free reaction protocol, 15 minutes reaction time and easy workup.

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