Magnesium Sulphate-Catalyzed Green and Efficient Synthesis of Some New Derivatives of 1-Amido Alkyl Naphthols under Solvent-Free Conditions

The present work describes an efficient, green, and direct approach for the synthesis of amido alkyl naphthols via one-pot multicomponent solvent-free reaction (MCR) of substituted aromatic aldehydes, beta-naphthols, and urea by the use of easily available, non-toxic, and cost-effective Lewis acid catalyst magnesium sulphate (MgSO4 center dot 7H(2)O). The important characteristics of this reaction include the following: eco-friendly and mild reaction conditions, excellent yields of the products, shorter reaction time, economically cheaper and environmentally friendly catalyst MgSO4 center dot 7H(2)O. Also, clean reaction, non-column purification, and operational simplicity are some of the additional significant features of this approach.

Automated summary

This study presents an efficient, green, and direct approach for the synthesis of amido alkyl naphthols, utilizing a one-pot multicomponent solvent-free reaction. The reaction is catalyzed by easily available, non-toxic, and cost-effective Lewis acid catalyst magnesium sulphate (MgSO4 center dot 7H(2)O). The important characteristics of this approach include eco-friendly and mild reaction conditions, excellent yields of the products, shorter reaction time, and economically cheaper and environmentally friendly catalyst.